PMID: 9418255Jan 7, 1998Paper

Streptomyces coelicolor DNA homologous with acyltransferase domains of type I polyketide synthase gene complex

FEMS Microbiology Letters
K KuczekM Mordarski

Abstract

An acyltransferase-homologous DNA fragment was amplified in a PCR reaction on a cosmid DNA template from the genomic DNA library of the soil bacterium Streptomyces coelicolor A3(2). The putative amino acid sequence of the fragment resembles acyl-CoA:ACP acyltransferase domains from several bacterial enzymatic complexes of polyketide synthase. There is a high similarity with acyltransferase domains from so-called type I polyketide synthases. Such synthases catalyze production of the aglycone portion of macrolides and polyethers that are important as antibiotics or immunosuppressants. The amplified fragment is considered to be a part of a larger gene complex.

References

Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·T SchweckeJ B Lester
May 15, 1994·FEMS Microbiology Letters·K KuczekM Goodfellow
Jan 1, 1993·Annual Review of Microbiology·L Katz, S Donadio
Jan 1, 1996·BioTechniques·N Hadjeb, G A Berkowitz

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Citations

Sep 30, 2006·Archives of Microbiology·Krzysztof PawlikEriko Takano
Dec 4, 2003·Journal of Biotechnology·T WeberW Wohlleben
Feb 13, 2001·Metabolic Engineering·W R Strohl
Jun 30, 2019·Applied Microbiology and Biotechnology·Bartosz BednarzKrzysztof J Pawlik
Jun 11, 2002·Microbiology·Magdalena KotowskaKatarzyna Kuczek

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