PMID: 2113916Jul 1, 1990Paper

Streptomyces relC mutants with an altered ribosomal protein ST-L11 and genetic analysis of a Streptomyces griseus relC mutant

Journal of Bacteriology
K Ochi

Abstract

Several relaxed (rel) mutants have been obtained from Streptomyces species by selecting colonies resistant to thiopeptin, an analogue of thiostrepton. Using two-dimensional gel electrophoresis, I compared the ribosomal proteins from rel and rel+ pairs of S. antibioticus, S. lavendulae, S. griseoflavus, and S. griseus. It was found that all of the Streptomyces rel mutants thus examined had an altered or missing ribosomal protein, designated tentatively ST-L11. These rel mutants therefore could be classified as relC mutants and were highly sensitive to erythromycin or high temperature. A relC mutant of S. griseus was defective in streptomycin production, but phenotypic reversion of this defect to normal productivity was found at high incidence among progeny of the relC mutant. This phenotypic reversion did not accompany a reappearance of ribosomal protein ST-L11, and furthermore the ability of accumulating ppGpp still remained at a low level, thus suggesting existence of a mutation (named sup) which suppresses the streptomycin deficiency phenotype exhibited by the relC mutant. Genetic analysis revealed that there is a correlation between the rel mutation and the inability to produce streptomycin or aerial mycelia. The sup mutatio...Continue Reading

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Citations

May 3, 1996·The Journal of Biological Chemistry·O H Martínez-CostaF Malpartida
Feb 27, 1999·Molecular Microbiology·P DuwatA Gruss
Sep 8, 2010·Nature Structural & Molecular Biology·Dawei SunJongkyeong Chung
May 26, 2011·Natural Product Reports·Gilles P van Wezel, Kenneth J McDowall
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·Kosaku TakahashiKozo Ochi
Sep 24, 2008·Applied Microbiology and Biotechnology·Deepak Singh, Shulin Chen
Dec 1, 1995·Microbiological Reviews·C CondonC L Squires
Apr 1, 1991·Journal of Bacteriology·K S KellyG H Jones
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Attia IramAli Demirci

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