PMID: 6108671May 1, 1980Paper

Streptomycin-induced defects of the otoconial membrane

Acta Oto-laryngologica
L G JohnssonP J Henry

Abstract

Damage to the neuro-epithelium caused by the vestibulotoxic drugs has been well described in previous reports; however, little is known about the effect of such drugs on the otoconia. In this investigation, streptomycin sulfate was found to create a circumscribed defect in the crystalline layer of the otoconial membrane in the utricle of the guinea pig. The defect was secondary to a sharply outlined lesion of the neuroepithelium which corresponded in size and location to the otoconial defect. Many of the otoconia along the margin of the defect showed signs of degeneration and appeared similar to those observed in the saccule of man during aging. In advanced stages of decay, the otoconia were reduced to hollow shells consisting of longitudinal interconnecting strands. All the epithelial lesions occurred with remarkable consistency in the same region of the macula utriculi at the posterior end of the striola.

References

Jul 1, 1977·Acta Oto-laryngologica·Y Harada, Y Sugimoto
Jul 1, 1972·The Laryngoscope·L G Johnsson, J E Hawkins
Apr 1, 1969·The Journal of Infectious Diseases·J E HawkinsJ M Aran
Sep 22, 1967·Science·L G Johnsson, J E Hawkins
Jan 1, 1980·Acta Oto-laryngologica·L G JohnssonP J Henry

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Citations

Jan 1, 1982·Audiology : Official Organ of the International Society of Audiology·K RejtöV Komora
Nov 13, 2013·Acta Oto-laryngologica·Leif Erik WaltherRüdiger Kniep
Jul 23, 2014·PloS One·Leif Erik WaltherRüdiger Kniep
Sep 4, 2016·HNO·L E Walther
Apr 1, 1983·Archives of Oto-rhino-laryngology·A Serra, I La Mantia
Jan 1, 1995·Acta Oto-laryngologica. Supplementum·F O BlackM F Reschke
Jul 1, 1997·Acta Oto-laryngologica·D AnastasopoulosA M Bronstein
Jun 18, 1999·Annals of the New York Academy of Sciences·T LempertA M Bronstein
Jan 1, 1984·Acta Oto-laryngologica. Supplementum·H YamaneH Rask-Andersen
Nov 17, 2001·Annals of the New York Academy of Sciences·R ThalmannI Thalmann
Jun 21, 2017·Vestnik otorinolaringologii·N L Kunel'skayaE A Manaenkova
Jul 1, 1984·Acta Oto-laryngologica·R C RouseJ E Hawkins
Dec 8, 2004·Developmental Biology·Inna HughesDavid M Ornitz

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