Streptozotocin, an inducer of NAD+ decrease, attenuates M-potassium current inhibition by ATP, bradykinin, angiotensin II, endothelin 1 and acetylcholine in NG108-15 cells

FEBS Letters
H HigashidaM Noda

Abstract

The M-potassium current was inhibited by bath application of 100 micron ATP, 10 nM bradykinin, 100 nM angiotensin II and 100 nM endothelin 1 as well as by 10 micron acetylcholine in an m1-muscarinic acetylcholine receptor-transformed NG108-15 cell line. The inhibition of M-current was attenuated in cells pretreated with 5 mM streptozotocin for 5-15 h and restored by simultaneous incubation with 5 mM nicotinamide. The results suggest that signal transduction from these five different receptors to M channels shares a common pathway which is susceptible to a streptozotocin-induced decrease in cellular NAD+ content.

References

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Dec 20, 1993·Annals of the New York Academy of Sciences·M NodaH Higashida

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Citations

Mar 12, 2003·Life Sciences·Sergei A GrandoIgnaz Wessler
Aug 26, 2000·Progress in Biophysics and Molecular Biology·B S Brown, S P Yu
Jun 27, 2006·Journal of Cellular and Molecular Medicine·Andrew Y Zhang, Pin-Lan Li
Feb 12, 2004·The Journal of Investigative Dermatology. Symposium Proceedings·Sergei A Grando
Oct 26, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Guo ZhangPin-Lan Li
Jul 17, 1998·Experimental Cell Research·S J LeeS S Shen

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