PMID: 26331889DOI: 10.1002/0471141755.ph0547s70Sep 4, 2015Paper
Streptozotocin-Induced Diabetic Models in Mice and Rats
Current Protocols in Pharmacology
Brian L Furman
Abstract
Streptozotocin (STZ) is an antibiotic that produces pancreatic islet β-cell destruction and is widely used experimentally to produce a model of type 1 diabetes mellitus (T1DM). Detailed in this unit are protocols for producing STZ-induced insulin deficiency and hyperglycemia in mice and rats. Also described are protocols for creating animal models for type 2 diabetes using STZ. These animals are employed for assessing the pathological consequences of diabetes and for screening potential therapies for the treatment of this condition.
References
Jul 30, 1976·Science·A A Like, A A Rossini
Sep 1, 1991·Diabetes·L G Weide, P E Lacy
Nov 1, 1990·Diabetes·J F FloodJ E Morley
Mar 1, 1990·Diabetes·J M HartnellA D Mooradian
Jul 1, 1987·Diabetes/metabolism Reviews·H Kolb
Jan 1, 1988·Diabetes·V Kolb-BachofenH Kolb
Oct 26, 1968·Lancet·M LazarT W Lieberman
Nov 1, 1969·The Journal of Clinical Investigation·A JunodA E Renold
Oct 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·A JunodA E Renold
Jan 1, 1967·Diabetes·R N ArisonM P Pruss
Aug 1, 1982·Diabetes·S G PaikS Shin
Apr 1, 1996·The Journal of Clinical Investigation·V V KunjathoorR C LeBoeuf
Mar 31, 1998·Diabetes·P MasielloG Ribes
Nov 25, 2000·Metabolism: Clinical and Experimental·M J ReedG M Reaven
Mar 27, 2003·Journal of Hypertension·Paul ChanJuei-Tang Cheng
Jul 17, 2003·Molecular Medicine·Jon G MableyCsaba Szabó
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Matthew D BreyerUNKNOWN AMDCC
May 27, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E BrøndumC Aalkjaer
Oct 29, 2005·The International Journal of Biochemistry & Cell Biology·Pellegrino Masiello
Dec 16, 2005·The Journal of Pharmacy and Pharmacology·Fengjie Huang, Wutong Wu
Aug 11, 2006·The Journal of Endocrinology·Paz VitalMarcia Hiriart
Sep 19, 2006·Atherosclerosis·Kenneth K Wu, Youming Huan
Nov 30, 2006·Diabetes·Dengping YinAnita S Chong
Nov 27, 2007·Nutrition & Metabolism·Seigo UsukiRobert K Yu
Apr 25, 2008·Current Protocols in Immunology·J Donovan, P Brown
Apr 25, 2008·Current Protocols in Immunology·John Donovan, Patricia Brown
Apr 25, 2008·Current Protocols in Immunology·John Donovan, Patricia Brown
Jan 9, 2009·American Journal of Physiology. Renal Physiology·Pengcheng LuoMong-Heng Wang
Jan 10, 2009·Experimental Diabetes Research·Ming ZhangLi Chen
Dec 17, 2009·Seizure : the Journal of the British Epilepsy Association·Mehdi GhasemiAhmad Reza Dehpour
Jun 30, 2010·Diabetes·Marvin LinBernd Schröppel
Apr 12, 2011·Laboratory Animals·M C DeedsY C Kudva
Apr 17, 2013·BMC Ophthalmology·Jorge E ManciniJuan E Gallo
May 9, 2014·Current Diabetes Reviews·Bingxuan WangJohn J Pippin
Nov 21, 2014·Journal of Diabetes Investigation·Søs Skovsø
Dec 24, 2014·Acta Physiologica Hungarica·Asghar GhasemiS Jedi
Mar 12, 2015·Journal of Diabetes Research·Frederika Maria ByrneVictoria Chapman
❮ Previous
Next ❯
Citations
Jan 2, 2016·Neurochemical Research·Gustavo Sánchez-ChávezRocío Salceda
Oct 9, 2016·Food & Nutrition Research·Eric Lontchi-YimagouJulius Oben
Jan 17, 2017·Nitric Oxide : Biology and Chemistry·Sevda GheibiAsghar Ghasemi
Sep 16, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hong ZhengHongchang Gao
Jul 27, 2017·Canadian Journal of Physiology and Pharmacology·Zsófia MezeiGyula Szabó
Dec 3, 2017·Calcified Tissue International·Cedo M BagiEdwin Berryman
Nov 5, 2016·Food & Function·Kaiping WangYu Zhang
Dec 19, 2017·Frontiers in Immunology·Zhicheng XueYi Ma
Oct 19, 2017·The Journal of Biological Chemistry·Yi XiongYingying Wu
Jun 7, 2018·The Journal of Biological Chemistry·Diogo de Barros PeruchettiCelso Caruso-Neves
Aug 4, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alona FeldmanPhilippa Melamed
Feb 20, 2019·PloS One·Jongdee NopparatAmornrat Phongdara
Mar 9, 2019·Metabolic Brain Disease·Ghazaleh OmidiAlireza Komaki
Dec 15, 2018·The Journal of Physiology·Qilong FengPingnian He
Mar 19, 2019·British Journal of Pharmacology·Chiara Bianca Maria PlataniaClaudio Bucolo
Jan 11, 2017·Scientific Reports·Cheng-Hsien ChenYung-Ho Hsu
Jul 18, 2019·Journal of Leukocyte Biology·Mariana Camila Gonçalves MirandaAna Maria Caetano Faria
Nov 19, 2015·Frontiers in Cellular Neuroscience·Kana SaseHitoshi Takagi
Jul 6, 2018·Experimental Animals·Abdulsamad AlsalahiZahurin Mohamed
Nov 24, 2018·Scientific Reports·Sarah A MiddletonVinod Kumar
Nov 28, 2019·Journal of Cellular Physiology·Eman A ElbassuoniWagdу N Habeeb
Oct 28, 2019·Applied Biochemistry and Biotechnology·Sulistyo Emantoko Dwi PutraIda Bagus Made Artadana
Aug 2, 2019·Sensors·Aldo Moreno-OyervidesPablo Acedo
Aug 31, 2019·Journal of Clinical Medicine·Raquel VieiraEliana B Souto
Jan 21, 2020·Molecular Genetics & Genomic Medicine·Xindan XingKun Liu
Jan 25, 2020·Journal of Biochemical and Molecular Toxicology·Noha M GamilNihad I Eid
Jan 26, 2020·Archives of Physiology and Biochemistry·Ganiyu ObohSunday Idowu Oyeleye
Dec 17, 2019·Plastic and Reconstructive Surgery·Liu CanSong Chunli
Jan 22, 2020·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Maryam SafaviMohammad Rabbani
Jan 3, 2020·Current Alzheimer Research·Abeer M Rababa'hOmar F Khabour
Potential Antidiabetic Activity of Extracts and Isolated Compound from Adenosma bracteosum (Bonati).
Feb 6, 2020·Biomolecules·Ngoc Hong NguyenVan Giau Vo
Dec 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hiroshi Kitamura
Feb 7, 2020·Experimental Dermatology·Omer E KaymakcalanJason A Spector
Feb 26, 2020·Cells·Srinivas PittalaVarda Shoshan-Barmatz
Jan 17, 2019·Journal of Food and Drug Analysis·Timothy Sean KairupanAkio Inui
Oct 6, 2016·PloS One·Fang YuanWeizhou Zhang
Jun 23, 2020·Islets·Douglas O SobelLarry Mitnaul
May 8, 2020·Journal of Food Biochemistry·Rabia El Adaouia TalebSevgi Kolayli
Jul 18, 2018·Molecular Medicine Reports·Qi YuSiwang Wang
May 22, 2020·British Journal of Pharmacology·Chang Woo ChaeHo Jae Han
May 28, 2019·Aging·Fan YuChun Yang
Aug 15, 2020·Cell Proliferation·Ye LiAng Li
Apr 8, 2020·Archives of Physiology and Biochemistry·Yongliang LiuXinxin Xiang
Aug 19, 2020·Drug Development and Industrial Pharmacy·Diana G SamiHassan M E Azzazy
Aug 25, 2019·BMC Complementary and Alternative Medicine·Ru-Ming LiuJian-Hui Xiao
Sep 6, 2019·Apoptosis : an International Journal on Programmed Cell Death·Mengqiu WuZhanjun Jia
Aug 28, 2020·Diabetes, Obesity & Metabolism·Neil TandayFinbarr P M O'Harte
Aug 19, 2020·Andrology·Joana N SimasSandra M Miraglia
Jan 11, 2017·Metabolic Brain Disease·Hong ZhengHongchang Gao
Dec 7, 2017·Diabetes·Ruth Ibán-AriasKyriaki Thermos
❮ Previous
Next ❯
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