Streptozotocin induced hyperglycemia stimulates molecular signaling that promotes cell cycle reentry in mouse hippocampus

Life Sciences
Euitaek YangKodeeswaran Parameshwaran

Abstract

Cerebral atrophy resulting from neurodegeneration is highly prevalent in individuals with diabetes; however, the underlying mechanisms for diabetic neurodegeneration are not fully understood. Here we hypothesized that hyperglycemia induces molecular signaling that favors induction of proliferation in post mitotic, fully differentiated hippocampal neurons. Streptozotocin (150 mg/kg) was intraperitoneally injected to four months old male mice to induce diabetes. Hippocampal tissue was subjected to molecular analysis of wingless-related integration site, extracellular signal regulated kinase, and brain derived neurotrophic factor signaling, and cell cycle regulation. Hyperglycemia did not alter wingless-related integration site signaling or cyclin E levels in the hippocampus. There were reductions in extracellular signal regulated kinase activation and brain derived neurotrophic factor levels along with elevated cyclin D1 levels. These findings indicate that hyperglycemic conditions can stimulate cell cycle progression in the hippocampus in vivo. These new insights into the disease mechanisms could support the development of novel therapeutics aimed to provide neuroprotection in diabetic patients.

References

Sep 13, 2002·Journal of Alzheimer's Disease : JAD·Robert Bowser, Mark A Smith
Oct 22, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karl HerrupAgata Copani
Oct 28, 2005·Nature·Dieter-Chichung LieFred H Gage
Sep 1, 2006·Journal of the American Society of Nephrology : JASN·Chun-Liang LinFeng-Sheng Wang
Sep 28, 2006·Diabetes Care·Esther S C KorfLenore J Launer
Aug 19, 2007·Current Neurovascular Research·Zhao Zhong ChongKenneth Maiese
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Sandra M MorilloJosé M Frade
Dec 20, 2011·Hippocampus·Nino TabatadzeAryeh Routtenberg
Jan 25, 2012·The American Journal of the Medical Sciences·Cheng HoChun-Liang Lin
Jan 28, 2012·Pharmacology & Therapeutics·Sivasankaran Balaratnasingam, Aleksandar Janca
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Manuela BassoRajiv R Ratan
Jul 20, 2012·Journal of Neuroscience Research·Karina Hernández-Ortega, Clorinda Arias
Sep 18, 2012·Experimental Neurology·N WeishauptK Fouad
Jan 1, 2013·Molecular Cell·Ana Chocarro-CalvoCustodia García-Jiménez
Jan 26, 2013·Diabetes·Elisabeth A Northam, Fergus J Cameron
Apr 19, 2013·Molecular Medicine Reports·Yu LiuXueliang Xu
Jun 5, 2013·Molecular and Cellular Endocrinology·Ping JiaoHaiyan Xu
Aug 2, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ashley M FortressKaryn M Frick
Sep 21, 2013·Journal of Molecular Endocrinology·Custodia García-JiménezAntonio De la Vieja
Dec 19, 2013·Frontiers in Cellular Neuroscience·Carolina A OlivaNibaldo C Inestrosa
Dec 24, 2013·Trends in Endocrinology and Metabolism : TEM·Krisztina Marosi, Mark P Mattson
Jan 15, 2014·The American Journal of Pathology·Serena AbbondanteFrank M Laferla
Feb 20, 2014·Journal of Molecular Cell Biology·Nibaldo C Inestrosa, Lorena Varela-Nallar
Mar 22, 2014·Biomedical Reports·Ai ChenMeng Mao
Sep 10, 2014·Journal of Diabetes Research·Jian-Qin WangYu-Hong Jing

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Citations

Jun 4, 2019·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vanessa A ZborowskiCristina W Nogueira

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