Streptozotocin (STZ)-Induced Diabetes Affects Tissue Trace Element Content in Rats in a Dose-Dependent Manner.

Biological Trace Element Research
Mikhail Yu KarganovAnatoly V Skalny

Abstract

The objective of the present study was investigation of tissue trace element distribution in a streptozotocin model of DM1 in rats. DM1 was modeled in 2-month-old male Wistar rats (n = 30) using intraperitoneal injection of 45 mg/kg b.w. (STZ1) and 55 mg/kg b.w. streptozotocin (STZ2), whereas control animals were injected with physiological saline. The rats were subjected to oral glucose tolerance test (OGTT) and HbA1c level assessment at day 14. At day 30, blood serum, liver, kidney, and heart samples were collected for tissue trace element assessment using inductively coupled plasma mass spectrometry (ICP-MS). STZ-treated rats were characterized by lack of significant weight gain and elevated HbA1c and blood glucose levels. ICP-MS analysis demonstrated a dose-dependent accumulation of Cu, Mn, Mo, and Se levels in the liver. Correspondingly, the dose-dependent increase in renal Cu, Mn, V, and Zn levels was significant, whereas the observed trend for kidney V and Mo accumulation was nearly significant. The patterns of trace element content in the myocardium of STZ-exposed rats were quite different from those observed for liver and kidney. Only cardiac Zn content was characterized by a significant decrease. Serum Co, Cr, Cu, Se,...Continue Reading

References

Jan 1, 1984·The Journal of Nutrition·A L Lau, M L Failla
Feb 1, 1996·The American Journal of Physiology·A T OzcelikayS M Brichard
Feb 9, 2002·The Journal of Nutritional Biochemistry·R Saraswathi Panneerselvam, Swaminathan Govindaswamy
Feb 28, 2004·Journal of Inorganic Biochemistry·Buffie J ClodfelderJohn B Vincent
May 12, 2004·Journal of Inorganic Biochemistry·Katherine H ThompsonChris Orvig
Apr 25, 2006·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Bogusław MachalińskiElzbieta Dabkowska
May 16, 2009·The Journal of Nutritional Biochemistry·Judith JansenLothar Rink
Sep 22, 2009·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·S CivelekG Burçak
Feb 6, 2010·Health and Quality of Life Outcomes·Oddvar SolliI S Kristiansen
Aug 21, 2010·Endocrinology and Metabolism Clinics of North America·David M MaahsElizabeth J Mayer-Davis
Sep 8, 2010·Radiological Physics and Technology·Mamoru NagataKenya Murase
Jul 24, 2012·Free Radical Biology & Medicine·Srinivasan Dinesh KumarSamuel Sam Wah Tay
Oct 9, 2012·Toxicology Mechanisms and Methods·Bing LiLu Cai
Mar 21, 2013·American Journal of Physiology. Endocrinology and Metabolism·Sarah Weksler-ZangenItamar Raz
Nov 14, 2013·Biological Trace Element Research·Giovanni ForteRoberto Madeddu
Dec 1, 1983·Biological Trace Element Research·S A Spittle, M L Failla
Dec 10, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Ching-Chiang LinYeou-Lih Huang
Sep 10, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Alexey A TinkovAlexandr A Nikonorov
Jun 16, 2016·Lancet·Marian Rewers, Johnny Ludvigsson
Feb 16, 2017·Current Hypertension Reports·Sunil K PanchalLindsay Brown
Mar 10, 2017·IUBMB Life·Jennifer LoweElaine Hilário-Souza
Nov 18, 2017·The Review of Diabetic Studies : RDS·Karen L SøgaardSteffen U Thorsen
Apr 6, 2018·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Ashgan Abdalla AlghobashyRanda H Mohamed
Sep 29, 2018·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Susmita Barman, Krishnapura Srinivasan
Aug 21, 2019·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Afshin SamadiGeir Bjørklund

❮ Previous
Next ❯

Citations

Aug 14, 2020·Biological Trace Element Research·Cristhian Neftaly Sánchez-SolísSamuel Treviño

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.