Stress-activated afferent inputs into the anterior parvicellular part of the paraventricular nucleus of the hypothalamus: Insights into urocortin 3 neuron activation

Brain Research
Christine van-Hover, Chien Li

Abstract

Urocortin 3 (Ucn 3) is a member of the corticotropin-releasing factor family, which plays a major role in coordinating stress responses. Ucn 3 neurons in the anterior parvicellular part of the paraventricular nucleus of the hypothalamus (PVHap) provide prominent input into the ventromedial nucleus of the hypothalamus (VMH), a well known satiety center, where Ucn 3 acts to suppress feeding and modulate blood glucose levels. In the present study, we first determined that Ucn 3 expression in the PVHap was stimulated by acute restraint stress. We then performed retrograde tracing with fluorogold (FG) combined with immunohistochemistry for Fos as a marker for neuronal activation after restraint stress to determine the stress-activated afferent inputs into the PVHap. Substantial numbers of FG/Fos double labeled cells were found in the bed nucleus of the stria terminalis, the lateral septal nucleus, the medial amygdala, and a number of nuclei in the hypothalamus including the VMH, the arcuate nucleus, the posterior nucleus, and the ventral premammillary nucleus. In the brainstem, FG/Fos positive cells were found in the periaqueductal gray, the nucleus of the solitary tract, and the ventrolateral medulla. In conclusion, the present stu...Continue Reading

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