Stress and Alterations in Bones: An Interdisciplinary Perspective

Frontiers in Endocrinology
Pia-Maria WippertKarin Wuertz-Kozak

Abstract

Decades of research have demonstrated that physical stress (PS) stimulates bone remodeling and affects bone structure and function through complex mechanotransduction mechanisms. Recent research has laid ground to the hypothesis that mental stress (MS) also influences bone biology, eventually leading to osteoporosis and increased bone fracture risk. These effects are likely exerted by modulation of hypothalamic-pituitary-adrenal axis activity, resulting in an altered release of growth hormones, glucocorticoids and cytokines, as demonstrated in human and animal studies. Furthermore, molecular cross talk between mental and PS is thought to exist, with either synergistic or preventative effects on bone disease progression depending on the characteristics of the applied stressor. This mini review will explain the emerging concept of MS as an important player in bone adaptation and its potential cross talk with PS by summarizing the current state of knowledge, highlighting newly evolving notions (such as intergenerational transmission of stress and its epigenetic modifications affecting bone) and proposing new research directions.

References

May 18, 1995·The New England Journal of Medicine·G P Chrousos
Nov 1, 1994·Journal of Cellular Biochemistry·A M DelanyE Canalis
Mar 1, 1994·The Journal of Clinical Endocrinology and Metabolism·S J HolmesS M Shalet
Dec 1, 1993·Annals of Internal Medicine·G P ChrousosM Karl
Feb 1, 1993·Endocrine Reviews·E CorpasM R Blackman
Oct 1, 1995·Bone·D D ThompsonH Z Ke
Jun 18, 1998·Annals of the New York Academy of Sciences·B S McEwen
Mar 18, 2000·Proceedings of the Society for Experimental Biology and Medicine·J L LiuD LeRoith
Jun 8, 2000·Matrix Biology : Journal of the International Society for Matrix Biology·S Nomura, T Takano-Yamamoto
Mar 28, 2001·Annals of the New York Academy of Sciences·G P Chrousos
Dec 1, 2001·Bone·D PatschanF Buttgereit
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M R ForwoodM B Bennett
Feb 23, 2002·Journal of Biomechanics·X Edward GuoChi Hyun Kim
Mar 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ted S GrossSteven D Bain
Sep 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Daniel D BikleBernard P Halloran
Jul 18, 2003·Medical and Pediatric Oncology·Robert C Olney
Aug 26, 2003·Bulletin of Experimental Biology and Medicine·K S NeporadaL M Tarasenko
Oct 17, 2003·European Cells & Materials·A S Turner
Jan 24, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·J EmeritF Bricaire
May 5, 2004·Psychological Bulletin·Sally S Dickerson, Margaret E Kemeny
Oct 29, 2004·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carlton L SchwabStephen B Pruett
Dec 8, 2004·Physiology & Behavior·Robert AdamecPaul Burton
Jul 13, 2005·Pituitary·Tatiana ManciniAndrea Giustina
Jul 16, 2005·Stress : the International Journal on the Biology of Stress·Moisés Evandro Bauer
Aug 2, 2005·Journal of Cardiopulmonary Rehabilitation·Zoran S Nedeljkovic, Noyan Gokce
Nov 1, 2006·Proceedings of the National Academy of Sciences of the United States of America·Raz YirmiyaItai Bab
Jan 11, 2007·The Journal of Endocrinology·Christianne M A ReijndersPaul Lips
Sep 4, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B MezukS H Golden
Jun 19, 2008·The Journal of Sexual Medicine·Neal MehtaMahadevan Rajasekaran
Oct 17, 2008·Psychoneuroendocrinology·Ulrike RimmeleMarkus Heinrichs
Dec 3, 2008·Archives of Pediatrics & Adolescent Medicine·Lorah D DornSusannah Grimes
May 16, 2009·The Journal of Endocrinology·R Hardy, M S Cooper
May 19, 2009·Biological Psychiatry·Raz Yirmiya, Itai Bab

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Citations

Sep 13, 2019·The Journal of International Medical Research·Frédéric DutheilFrançois-Xavier Lesage
Jul 11, 2019·Journal of Epidemiology and Community Health·Shawna L FollisZhao Chen
Apr 20, 2018·International Journal of Environmental Research and Public Health·Pia-Maria Wippert, Christine Wiebking
Sep 27, 2018·Frontiers in Endocrinology·Paula Suarez-BreguaJosep Rotllant
Sep 16, 2020·International Journal of Molecular Sciences·Karin Wuertz-KozakPia M Wippert
Feb 3, 2020·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·W WongtrakulP Ungprasert
Oct 20, 2018·Archives of Oral Biology·Emisael Stênio Batista GomesAndré Luiz Sena Guimarães
May 28, 2021·Journal of Epidemiology and Community Health·Shawna FollisZhao Chen
Jul 1, 2021·BioMed Research International·Chao WangChengai Wu

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