Mar 15, 2008

Stress and childhood asthma risk: overlapping evidence from animal studies and epidemiologic research

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
Rosalind J Wright


: Rapidly expanding evidence increasingly strengthens the evidence linking psychological factors to asthma and allergy expression. Parallel studies in animals and humans demonstrating the influence of prenatal maternal stress and early caregiving experiences on the disrupted regulation of defensive biological systems [eg, sympathetic and adrenomedullary (SAM) system and the hypothalamicpituitary-adrenocortical (HPA) axis] provide strong proof of concept for this line of research. The consequent altered neuroimmune responses may influence the expression of immune-mediated disorders such as asthma as well as enhance an individual's susceptibility to other environmental factors that may also contribute to asthma risk.

  • References59
  • Citations12


Mentioned in this Paper

Biochemical Pathway
Biological Adaptation to Stress
Entire Fetus
Glucocorticoid inhalants for obstructive airway disease
Nonhuman primate
Pituitary Diseases
Health Outcomes
Neurosecretory Systems

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