Stress and corticotropin releasing factor (CRF) promote necrotizing enterocolitis in a formula-fed neonatal rat model.

PloS One
Robert L BellAditi Bhargava

Abstract

The etiology of necrotizing enterocolitis (NEC) is not known. Alterations in gut microbiome, mucosal barrier function, immune cell activation, and blood flow are characterized events in its development, with stress as a contributing factor. The hormone corticotropin-releasing factor (CRF) is a key mediator of stress responses and influences these aforementioned processes. CRF signaling is modulated by NEC's main risk factors of prematurity and formula feeding. Using an established neonatal rat model of NEC, we tested hypotheses that: (i) increased CRF levels-as seen during stress-promote NEC in formula-fed (FF) newborn rats, and (ii) antagonism of CRF action ameliorates NEC. Newborn pups were formula-fed to initiate gut inflammation and randomized to: no stress, no stress with subcutaneous CRF administration, stress (acute hypoxia followed by cold exposure-NEC model), or stress after pretreatment with the CRF peptide antagonist Astressin. Dam-fed unstressed and stressed littermates served as controls. NEC incidence and severity in the terminal ileum were determined using a histologic scoring system. Changes in CRF, CRF receptor (CRFRs), and toll-like receptor 4 (TLR4) expression levels were determined by immunofluorescence and ...Continue Reading

References

Mar 5, 2002·Clinical Endocrinology·Roel J BoltHenriette A Delemarre-Van De Waal
Oct 22, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Johan D SöderholmMary H Perdue
Nov 9, 2002·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Wei HsuehF Gonzalez-Crussi
Jan 28, 2004·Annual Review of Pharmacology and Toxicology·Tracy L Bale, Wylie W Vale
May 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susanne E la FleurAditi Bhargava
Jun 24, 2005·The Journal of Pediatrics·Philip T NowickiDonna A Caniano
Aug 9, 2005·Seminars in Pediatric Surgery·Josef NeuElizabeth Beierle
Aug 9, 2005·Seminars in Pediatric Surgery·Michael S CaplanTamas Jilling
Aug 9, 2005·Seminars in Pediatric Surgery·Philip T Nowicki
Nov 5, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Melissa D HalpernBohuslav Dvorak
Jan 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christos TsatsanisAndrew N Margioris
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tamas JillingMichael S Caplan
Sep 20, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cynthia L LeaphartDavid J Hackam
Dec 20, 2007·Pediatric Research·Catherine J HunterVictoria Camerini
Jun 10, 2008·Current Molecular Medicine·Mélanie G GareauMary H Perdue
Jun 10, 2008·Current Molecular Medicine·Femke LutgendorffJohan D Söderholm
Mar 21, 2009·Pediatric Surgery International·Mikael PetrosyanHenri R Ford
May 13, 2009·Reproductive Biology and Endocrinology : RB&E·Binhai CongXin Ni
Jun 9, 2009·Journal of Pediatric Gastroenterology and Nutrition·Mustafa KulFaruk Alpay
Jul 18, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yuying LiuJon Marc Rhoads
Feb 13, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A V KeitaA-C Ericson
Apr 10, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A V Keita, J D Söderholm
Apr 30, 2010·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·E JorgeM T Martin
Oct 1, 2010·Experimental Biology and Medicine·Andreas Stengel, Yvette Taché
Oct 13, 2010·Proceedings of the National Academy of Sciences of the United States of America·Adi Neufeld-CohenAlon Chen
Feb 19, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jen ChangAditi Bhargava
May 5, 2011·Frontiers in Neuroscience·Roeland BuckinxJean-Pierre Timmermans
Jun 21, 2011·Journal of Pediatric Surgery·Cynthia D DownardRichard N Garrison
Jul 9, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Steven J McElroyD Brent Polk

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