Stress and hippocampal abnormalities in psychiatric disorders

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Michela SalaPaolo Brambilla

Abstract

The hippocampus plays a main role in regulating stress response in humans, but is itself highly sensitive to neurotoxic effects of repeated stressful episodes. Hippocampal atrophy related to experimental stress has been reported in laboratory studies in animals. Several controlled brain imaging studies have also shown hippocampal abnormalities in psychiatric disorders, including posttraumatic stress disorder (PTSD), major depressive disorder (MDD), and borderline personality disorder (BPD). This paper reviews the physiological role of the hippocampus in stress circuitry and the effects of stress on cognitive functions mediated by the hippocampus. We also review brain imaging studies investigating hippocampus in PTSD, MDD, and BPD. This literature suggests that individuals with PTSD, MDD, and BPD may suffer hippocampal atrophy as a result of stressors associated with these disorders. Prospective, longitudinal studies will be needed in high-risk offspring and first-episode subjects to explore the relationship between stress and hippocampal atrophy in these neuropsychiatric illnesses.

References

Apr 13, 1992·Neuroscience Letters·K MizoguchiT Tabira
Nov 3, 1992·European Journal of Pharmacology·Y WatanabeB S McEwen
Aug 1, 1986·Endocrine Reviews·R M SapolskyB S McEwen
Aug 1, 1983·The Journal of Comparative Neurology·P E Sawchenko, L W Swanson
Apr 1, 1995·Current Opinion in Neurobiology·L R Squire, P Alvarez
Apr 1, 1995·Current Opinion in Neurobiology·B S McEwen, R M Sapolsky
May 1, 1993·Psychiatry Research·D A AxelsonK R Krishnan
Jan 1, 1993·Brain Research. Brain Research Reviews·F Chaouloff
Apr 30, 1996·Proceedings of the National Academy of Sciences of the United States of America·Y I ShelineM W Vannier
Aug 9, 1996·Science·R M Sapolsky
Feb 1, 1997·Trends in Neurosciences·J P Herman, W E Cullinan
Jun 1, 1997·Brain Research. Brain Research Reviews·S J Lupien, B S McEwen
Jul 1, 1997·Psychological Medicine·M B SteinB McClarty
Jun 21, 1997·Annals of the New York Academy of Sciences·N SchuffM W Weiner
Jul 1, 1997·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·R A Poldrack, J D Gabrieli
Feb 12, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M MagariñosB S McEwen
Dec 24, 1997·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·B S McEwenC McKittrick
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·E GouldE Fuchs
Apr 17, 1998·European Journal of Pharmacology·C TadokoroK Kamijima
Jul 11, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T W FreemanR A Komoroski
Jul 31, 1998·Trends in Neurosciences·L Cahill, J L McGaugh
Oct 30, 1998·Psychological Medicine·L V Kessing
Nov 26, 1998·The British Journal of Psychiatry : the Journal of Mental Science·P J ShahG M Goodwin
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Jul 15, 1999·Psychological Medicine·M AshtariS Pollack
Feb 9, 2000·The Journal of Nervous and Mental Disease·M C ZanariniJ G Gunderson
Mar 18, 2000·Psychological Medicine·E MervaalaJ Lehtonen
Apr 12, 2000·Kidney International·E R de KloetW de Jong

❮ Previous
Next ❯

Citations

Nov 5, 2008·Current Psychiatry Reports·Paolo BrambillaJair C Soares
Nov 14, 2008·Biological Psychiatry·Tibor HajszanRonald S Duman
Aug 21, 2008·Psychological Medicine·M SalaP Brambilla
Apr 15, 2006·Development and Psychopathology·Abigail A BairdC Elizabeth Rabbitt
Jan 28, 2010·Development and Psychopathology·Hilary K MeadKatherine E Shannon
Jul 11, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Amanda J LawPaul J Harrison
Dec 14, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yogesh DwivediGhanshyam N Pandey
Sep 1, 2007·Behavioural Pharmacology·Benicio N FreyFlávio Kapczinski
Sep 2, 2009·Neuropsychiatric Disease and Treatment·Yogesh Dwivedi
Jan 26, 2013·Annals of Indian Academy of Neurology·Kuljeet Singh Anand, Vikas Dhikav
Jan 25, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Gloria MilesiCarolina Frassoni
May 22, 2010·Expert Opinion on Emerging Drugs·Marsal SanchesJair C Soares
Apr 11, 2013·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Yogesh Dwivedi
Apr 26, 2011·Journal of Chemical Neuroanatomy·Yogesh Dwivedi
Nov 16, 2010·Biological Psychiatry·Natalie C TronsonJelena Radulovic
Oct 12, 2010·European Psychiatry : the Journal of the Association of European Psychiatrists·E RodriguesI R de Oliveira
Jan 12, 2010·Neuropharmacology·Nathan A DeCarolis, Amelia J Eisch
Feb 25, 2009·Journal of Affective Disorders·Valentina LorenzettiMurat Yücel
Dec 24, 2008·Pharmacology, Biochemistry, and Behavior·Xue-Min GaoCarol A Tamminga
Dec 23, 2006·Psychiatry Research·Kalliopi TournikiotiPaolo Brambilla
Apr 28, 2006·Acta Psychiatrica Scandinavica·P AdamiA Conca
Nov 29, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Songhee JeonSok Cheon Pak
Jun 9, 2005·Biological Psychiatry·Yogesh DwivediRobert R Conley
Oct 13, 2005·Neuroscience Letters·Sven HendrixMarcus Maurer
Jun 21, 2005·Psychoneuroendocrinology·Miranda OlffBerthold P R Gersons
Apr 14, 2005·The Psychiatric Clinics of North America·Paolo BrambillaJair C Soares
Jul 11, 2013·BioMed Research International·Badriya Al-RahbiWan Mohd Zahiruddin Wan Mohammad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.