Stress and immune biomarkers interact with parenting behavior to shape anxiety symptoms in trauma-exposed youth

Psychoneuroendocrinology
Karen YirmiyaRuth Feldman

Abstract

The relations between stress, HPA-axis, and the immune system have been extensively studied; however, no study to date addressed the joint contribution of immune and HPA biomarkers to the development of anxiety in youth exposed to chronic trauma as mediated by mother-child interaction patterns. A unique cohort of war-exposed children and their mothers, compared to matched controls, were followed from infancy and the current study reports findings from early adolescence (mean age = 11.66, SD = 1.23; N = 111; exposed = 58 control = 53). Youth and mothers' salivary cortisol (CT) and secretory immunoglobulin (s-IgA) levels were measured three times during a 4-hour lab visit, mother-child interaction patterns were quantified from a joint task, and children's anxiety symptoms diagnosed. Trauma-exposed children had higher levels of CT and s-IgA, exhibited more anxiety symptoms, and showed lower social collaboration with mother during the joint task. Trauma-exposed mothers had higher CT and s-IgA levels and showed less supportive parenting during mother-child interaction. Structural equation modeling defined three bio-behavioral paths by which trauma increases anxiety in youth. While the first path charted a behavioral link from exposu...Continue Reading

Citations

May 13, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Ruth Feldman
Jul 10, 2020·International Journal of Molecular Sciences·Elke HumerThomas Probst
Sep 3, 2019·Frontiers in Psychiatry·Jonathan LevyRuth Feldman
Apr 10, 2020·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Karen YirmiyaRuth Feldman
Jan 13, 2021·Annual Review of Clinical Psychology·Ruth Feldman

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