Stress and immune responses after surgical treatment for regional breast cancer

Journal of the National Cancer Institute
Barbara L AndersenR Glaser

Abstract

Adults who undergo chronic stress, such as the diagnosis and surgical treatment of breast cancer, often experience adjustment difficulties and important biologic effects. This stress can affect the immune system, possibly reducing the ability of individuals with cancer to resist disease progression and metastatic spread. We examined whether stress influences cellular immune responses in patients following breast cancer diagnosis and surgery. We studied 116 patients recently treated surgically for invasive breast cancer. Before beginning their adjuvant therapy, all subjects completed a validated questionnaire assessing the stress of being cancer patients. A 60-mL blood sample taken from each patient was subjected to a panel of natural killer (NK) cell and T-lymphocyte assays. We then developed multiple regression models to test the contribution of psychologic stress in predicting immune function. All regression equations controlled for variables that might exert short- or long-term effects on these responses, and we also ruled out other potentially confounding variables. We found, reproducibly between and within assays, the following: 1) Stress level significantly predicted lower NK cell lysis, 2) stress level significantly pred...Continue Reading

Associated Clinical Trials

References

Apr 16, 1977·Lancet·R W BartropR Penny
Jul 1, 1979·British Journal of Cancer·P HerseyW H McCarthy
May 1, 1979·Psychosomatic Medicine·M HorowitzW Alvarez
Jul 1, 1991·Psychosomatic Medicine·J K Kiecolt-GlaserR Glaser
Aug 1, 1990·Journal of Personality and Social Psychology·R S BaronD M Lubaroff
May 1, 1990·Immunopharmacology·M P Nair, S A Schwartz
Dec 1, 1989·Journal of Consulting and Clinical Psychology·B L AndersenC deProsse
Jan 1, 1989·Advances in Immunology·G Trinchieri
Jan 1, 1985·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·J K Kiecolt-GlaserG Bonnell
Mar 1, 1988·Brain, Behavior, and Immunity·J K Kiecolt-Glaser, R Glaser
Jun 1, 1986·The British Journal of Surgery·J R MonsonP J Guillou
Jan 1, 1985·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·S M LevyM Lippman
Dec 1, 1973·The Journal of Surgical Research·A V JubertC M McBride
Jan 15, 1980·International Journal of Cancer. Journal International Du Cancer·G B CannonN P Lang
Sep 1, 1984·Psychosomatic Medicine·S E LockeR M Williams
Oct 2, 1981·Science·R B Herberman, J R Ortaldo
Nov 4, 1995·Lancet·J K Kiecolt-GlaserR Glaser
Mar 1, 1994·Clinical and Diagnostic Laboratory Immunology·T L Whiteside, R B Herberman
Feb 1, 1995·Current Opinion in Immunology·P Scott, G Trinchieri
Jul 1, 1994·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·B A EsterlingR Glaser
May 1, 1994·The American Psychologist·B L AndersenR Glaser
Aug 15, 1994·Cancer·B L Andersen
May 1, 1993·Psychological Bulletin·T B Herbert, S Cohen
Mar 1, 1993·Journal of Clinical Immunology·M SchedlowskiR E Schmidt
Jul 1, 1993·Psychosomatic Medicine·T B Herbert, S Cohen
Apr 2, 1996·Proceedings of the National Academy of Sciences of the United States of America·J K Kiecolt-GlaserJ Sheridan
Jan 16, 1981·Science·A Hills, M G Morgan
Jun 1, 1996·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·A Moyer, P Salovey

❮ Previous
Next ❯

Citations

Mar 21, 2012·Der Anaesthesist·K FukuiG Pestel
Jun 19, 2012·Cancer Causes & Control : CCC·Patrick PösselJeffrey C Valentine
Mar 6, 2010·Journal of Behavioral Medicine·Salene M Wu, Barbara L Andersen
Jul 14, 2006·Quality of Life Research : an International Journal of Quality of Life Aspects of Treatment, Care and Rehabilitation·Heather S JimBarbara L Andersen
Apr 5, 2011·Medical Oncology·Faruk TasFatma Ebru Cinar
May 14, 2005·Brain, Behavior, and Immunity·Phillip T MaruchaBarbara L Andersen
Mar 9, 2005·Biochemical and Biophysical Research Communications·Fengxi SuErwei Song
Oct 4, 2002·Biological Psychiatry·K Ranga R KrishnanCynthia Wainscott
Oct 8, 2003·Patient Education and Counseling·B De Brabander, P Gerits
Jul 2, 2003·Brain, Behavior, and Immunity·Susan K Lutgendorf, Erin S Costanzo
Feb 16, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J K Kiecolt-Glaser, R Glaser
May 16, 2002·BJOG : an International Journal of Obstetrics and Gynaecology·Rodney W Petersen, Julie A Quinlivan
Mar 22, 2002·The Lancet Oncology·E ErnstE Ross
Sep 21, 2004·Breast Cancer Research and Treatment·Marzio E E SabbioniUNKNOWN Swiss Group for Clinical Cancer Research (SAKK)
Jul 15, 2004·Psychological Bulletin·Suzanne C Segerstrom, Gregory E Miller
May 19, 2005·Health Psychology : Official Journal of the Division of Health Psychology, American Psychological Association·Deanna M Golden-KreutzBarbara L Andersen
Feb 25, 2006·Nature Reviews. Cancer·Michael H AntoniAnil K Sood
Oct 11, 2008·Nature Reviews. Cancer·Bostjan SerugaIan F Tannock
Sep 10, 2010·The Journal of Biological Chemistry·Mian M K ShahzadAnil K Sood
Jan 1, 2009·Health Care for Women International·Shirley A Thomas, A Antonio González-Prendes
May 12, 2010·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Carolyn Y FangSteven D Douglas
Jul 16, 2010·British Journal of Anaesthesia·G L Snyder, S Greenberg
Jun 6, 2007·Evidence-based Complementary and Alternative Medicine : ECAM·Lei WangTetsuya Konishi
Jul 28, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Mayank ThakurVinod K Dixit
Jan 15, 1998·Journal of the National Cancer Institute·S Cohen, B S Rabin
Nov 18, 2005·ANS. Advances in Nursing Science·Nancy L McCainJoLynne Robins
Oct 25, 2011·Psychosomatic Medicine·Susan K Lutgendorf, Anil K Sood
Jul 23, 1999·Annals of the New York Academy of Sciences·M P EversonW D Blackburn
Mar 13, 1999·Annual Review of Psychology·A Baum, D M Posluszny
Mar 13, 1999·Annual Review of Psychology·J T Cacioppo, W L Gardner
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Susan K LutgendorfAnil K Sood
Jun 10, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Barbara L AndersenWilliam E Carson
Apr 6, 2011·Cancer Prevention Research·Anil K Sood, Susan K Lutgendorf
Oct 9, 2002·The Journal of Clinical Investigation·Robin PariharWilliam E Carson
Jan 8, 2003·Psychosomatics·Karen HjerlTorben Jørgensen
Jan 8, 2005·BMC Medical Research Methodology·Leslie A HaydukMelanie A Beres
Feb 10, 2007·Clinical Practice and Epidemiology in Mental Health : CP & EMH·Massimo Pasquini, Massimo Biondi
Apr 19, 2013·Biology of Sex Differences·Christina L NemethGretchen N Neigh
Sep 1, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara L AndersenWilliam E Carson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Barbara L AndersenWilliam E Carson
Journal of the National Cancer Institute
S Cohen, B S Rabin
The American Psychologist
Barbara L AndersenR Glaser
© 2021 Meta ULC. All rights reserved