PMID: 2568569Jan 1, 1989Paper

Stress and immunity: an integrated view of relationships between the brain and the immune system

Life Sciences
R Dantzer, K W Kelley


The old notion that stress exacerbates the progression of physical illness via its corticosteroid-mediated immunosuppressive effects must be revised. Experimental and clinical studies demonstrate that both laboratory and natural stressors alter the activities of lymphocytes and macrophages in a complex way that depends on the type of immune response, the physical and psychological characteristics of the stressor and the timing of stress relative to the induction and expression of the immune event. The influences of stress on immunity are mediated not only by glucocorticoids but also by catecholamines, endogenous opioids and pituitary hormones such as growth hormone. Sensitivity of the immune system to stress is not simply fortuitous but is an indirect consequence of the regulatory reciprocal influences that exist between the immune system and the central nervous system. The immune system receives signals from the brain and the neuroendocrine system via the autonomic nervous system and hormones and sends information to the brain via cytokines. These connections appear to be part of a long-loop regulatory feedback system that plays an important role in the coordination of behavioral and physiological responses to infection and in...Continue Reading

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Apr 16, 1977·Lancet·R W BartropR Penny
Oct 13, 1979·Lancet·S GreerK W Pettingale
Aug 3, 1979·Science·L S Sklar, H Anisman
Dec 1, 1979·Cellular Immunology·H O BesedovskyH H Keller
Apr 15, 1977·Science·A A Monjan, M I Collector
Nov 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H BesedovskyJ Müller
Jan 1, 1986·Annual Review of Pharmacology and Toxicology·G J Mannering, L B Deloria
Mar 1, 1989·Biochemical Pharmacology·K W Kelley
Mar 1, 1987·Brain, Behavior, and Immunity·R GlaserM Beck
Jan 1, 1988·Annual Review of Immunology·N E Sibinga, A Goldstein
Jan 1, 1988·International Journal of Immunopharmacology·P O OgunbiyiP Eyre
Jun 1, 1986·The Journal of Experimental Medicine·H J WestlyP H Yuen
Nov 29, 1985·Science·B M WoloskiJ E Blalock
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y ShavitJ C Liebeskind
Jan 1, 1987·Psychosomatic Medicine·J K Kiecolt-GlaserR Glaser
Jun 1, 1987·Proceedings of the Society for Experimental Biology and Medicine·H J Westly, K W Kelley
Aug 14, 1987·Biochemical and Biophysical Research Communications·A UeharaA Arimura
Sep 1, 1988·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D A WeigentJ E Blalock
Jan 1, 1988·The Japanese Journal of Physiology·M Iriki
Aug 1, 1988·Journal of Animal Science·K W Kelley
Apr 15, 1988·Biological Psychiatry·D V HarbourW J Meyer
Apr 19, 1988·Brain Research·F CoceaniC A Dinarello
Jan 1, 1988·Annual Review of Medicine·B Beutler, A Cerami
Apr 1, 1988·Brain : a Journal of Neurology·F GrayF Scaravilli
Jul 1, 1988·The Journal of Experimental Medicine·D L FrakerJ A Norton
Nov 1, 1987·The American Journal of Physiology·A del Rey, H Besedovsky
Dec 1, 1987·Immunological Reviews·W L FarrarM Vinocour
Mar 1, 1988·The Journal of Experimental Medicine·K J TraceyA Cerami
Jun 1, 1988·The Journal of Experimental Medicine·S H SocherD Martinez
Mar 1, 1987·Brain, Behavior, and Immunity·M IrwinH Weiner
Feb 23, 1987·Life Sciences·G CroisetR E Ballieux
Jul 1, 1987·The American Journal of Physiology·S ShohamJ M Krueger

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Nov 1, 1992·Journal of Medical Virology·D Ben-NathanG Feuerstein
May 1, 1994·Naunyn-Schmiedeberg's Archives of Pharmacology·I T BognarH Fuder
May 1, 1993·Cell and Tissue Research·H J Krammer, W Kühnel
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·A FerryM Rieu
Jan 1, 1992·European Journal of Applied Physiology and Occupational Physiology·E OrtegaM De la Fuente
Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·E OrtegaM De la Fuente
Feb 1, 1995·Molecular Neurobiology·F ShintaniM Asai
Jul 1, 2000·Indian Journal of Clinical Biochemistry : IJCB·P K MedirattaS G Chowdhury
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Clarisa M BucknerJoan W Berman
Jun 21, 2012·Neurotoxicity Research·Kenneth H ClarkCharles W Bradberry
Mar 20, 2012·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eduardo A PinedaAndréy M Mazarati
Aug 3, 1993·Biochemical Pharmacology·P K PetersonC C Chao
Nov 21, 1989·European Journal of Pharmacology·J D ChristensenB Fjalland
Jan 1, 1991·Journal of Psychosomatic Research·A Steptoe
Jul 1, 1995·Journal of Psychosomatic Research·K M PaarlbergH P Van Geijn
Jan 1, 1990·Life Sciences·E FrideP K Arora
Sep 1, 1992·Mechanisms of Ageing and Development·E OrtegaM De la Fuente
Aug 1, 1993·Mechanisms of Ageing and Development·E OrtegaM De la Fuente
Dec 1, 1990·Pharmacology, Biochemistry, and Behavior·C R Prince, H Anisman
Jun 1, 1991·Pharmacology, Biochemistry, and Behavior·S ZalcmanH Anisman
May 1, 1994·Pharmacology, Biochemistry, and Behavior·S PuriP Sen
Oct 1, 1995·Pharmacology, Biochemistry, and Behavior·M S ExtonA J Husband
May 1, 1996·Pharmacology, Biochemistry, and Behavior·T MarottiH Haberstock
Aug 1, 1990·Journal of Affective Disorders·B O'Neill, B E Leonard
Apr 16, 1996·Psychiatry Research·F BrambillaA Panerai
Mar 1, 1995·Veterinary Immunology and Immunopathology·M J HessingC Renard
Oct 1, 1994·Veterinary Immunology and Immunopathology·K W KelleyR Dantzer
Aug 1, 1991·Immunology Letters·A FerryM Rieu

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