Stress and matrix-responsive cytoskeletal remodeling in fibroblasts.

Journal of Cellular Physiology
Rosalyn D AbbottHelene M Langevin

Abstract

In areolar "loose" connective tissue, fibroblasts remodel their cytoskeleton within minutes in response to static stretch resulting in increased cell body cross-sectional area that relaxes the tissue to a lower state of resting tension. It remains unknown whether the loosely arranged collagen matrix, characteristic of areolar connective tissue, is required for this cytoskeletal response to occur. The purpose of this study was to evaluate cytoskeletal remodeling of fibroblasts in, and dissociated from, areolar and dense connective tissue in response to 2 h of static stretch in both native tissue and collagen gels of varying crosslinking. Rheometric testing indicated that the areolar connective tissue had a lower dynamic modulus and was more viscous than the dense connective tissue. In response to stretch, cells within the more compliant areolar connective tissue adopted a large "sheet-like" morphology that was in contrast to the smaller dendritic morphology in the dense connective tissue. By adjusting the in vitro collagen crosslinking, and the resulting dynamic modulus, it was demonstrated that cells dissociated from dense connective tissue are capable of responding when seeded into a compliant matrix, while cells dissociated f...Continue Reading

References

Jan 1, 1991·Proceedings of the Society for Experimental Biology and Medicine·K M Reiser
Jun 5, 1999·Journal of Biomedical Materials Research·T S GirtonR T Tranquillo
Mar 29, 2001·Diabetologia·R SinghL Beilin
Apr 3, 2001·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·D McCombeW A Morrison
Oct 7, 2003·Archives of Histology and Cytology·Seiichi KawamataHarumichi Shinohara
Oct 22, 2004·American Journal of Physiology. Cell Physiology·Helene M LangevinAlan K Howe
Jul 25, 2006·Acta Biomaterialia·Tumul Gupta, Tammy L Haut Donahue
May 14, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Rani RoyLawrence J Bonassar
Dec 5, 2009·BMC Musculoskeletal Disorders·Helene M LangevinSharon M Henry
Mar 20, 2010·Histochemistry and Cell Biology·Helene M LangevinDouglas J Taatjes
Oct 15, 2010·Journal of Cellular Physiology·Helene M LangevinAlan K Howe
May 26, 2011·Nature Reviews. Endocrinology·Helen Vlassara, Gary E Striker
Sep 21, 2011·BMC Musculoskeletal Disorders·Helene M LangevinSharon M Henry

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Citations

Jan 1, 2014·Tissue Engineering. Part a·Nicky de JongeCarlijn V C Bouten
Mar 7, 2013·Cell Calcium·Nanna GoldmanTakahiro Takano
Feb 28, 2013·Journal of Cellular Biochemistry·Helene M LangevinAlan K Howe
Sep 18, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Chun YangLin Yuan
Sep 12, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Bruno Bordoni, Emiliano Zanier
May 10, 2017·Physiotherapy Theory and Practice·Sudarshan Anandkumar, Murugavel Manivasagam
Mar 13, 2018·Physiotherapy Theory and Practice·Sudarshan Anandkumar, Murugavel Manivasagam
Aug 12, 2017·Clinical Hemorheology and Microcirculation·Xinxiao HanDong Han
Feb 8, 2018·Medical Acupuncture·Conner E Liddle, Richard E Harris
Feb 24, 2018·Physiotherapy Theory and Practice·Sudarshan Anandkumar
Oct 18, 2012·Nature Reviews. Molecular Cell Biology·Peter FriedlKenneth M Yamada
Aug 7, 2019·Experimental and Therapeutic Medicine·Andrea BuscemiMarinella Coco
May 23, 2021·Current Opinion in Genetics & Development·Dongsheng Jiang, Yuval Rinkevich
Aug 28, 2021·International Journal of Molecular Sciences·Dongsheng Jiang, Yuval Rinkevich

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