Stress and pain response after oligofructose induced-lameness in dairy heifers

Journal of Veterinary Science
Hedie BustamanteMarianne P Werner

Abstract

Lameness is one of the most painful conditions that affects dairy cattle. This study was conducted to evaluate clinical signs and plasma concentration of several pain and stress biomarkers after oligofructose-induced lameness in dairy heifers. Lameness was induced using an oligofructose overload model in 12 non-pregnant heifers. Clinical parameters and blood samples were obtained at 48 and 24 h and at 6, 12, 24, 36 and 48 h after induction of lameness. Clinical parameters included heart rate, respiratory rate, ruminal frequency and lameness score. Plasma biomarkers included cortisol, haptoglobin, norepinephrine, beta-endorphin and substance P. Differences were observed in all parameters between control and treated heifers. The plasma concentration of biomarkers increased significantly in treated animals starting 6 h after induction of lameness, reaching maximum levels at 24 h for cortisol, 48 h for haptoglobin, 6 h for norepinephrine, 12 h for substance P and at 24 h for beta-endorphin. Overall, our results confirm that lameness associated pain induced using the oligofructose model induced changes in clinical parameters and plasma biomarkers of pain and stress in dairy heifers.

References

Apr 1, 1993·Baillière's Clinical Endocrinology and Metabolism·P Hjemdahl
Sep 1, 1995·Journal of Animal Science·A M Lefcourt, T H Elsasser
Jan 1, 1997·Journal of Animal Science·T Grandin
May 27, 1999·The Veterinary Record·N U HoradagodaP D Eckersall
Sep 18, 2004·Journal of Dairy Science·M B ThoefnerP H Andersen
Apr 9, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ichiro KondoTony L Yaksh
Jul 20, 2005·Journal of Dairy Science·M B ThoefnerS S Nielsen
Oct 13, 2005·New Zealand Veterinary Journal·K J Stafford, D J Mellor
Dec 17, 2005·Journal of Dairy Science·F C Flower, D M Weary
Jan 27, 2006·Journal of Applied Animal Welfare Science : JAAWS·Leena AnilJohn Deen
Jan 20, 2007·Physiology & Behavior·Pierre MormèdeIsabelle Veissier
Jun 4, 2008·American Journal of Veterinary Research·J F CoetzeeMichael D Apley
Jan 24, 2009·Journal of Dairy Science·A M DanscherM B Thoefner
Jul 23, 2009·Clinical Drug Investigation·Antonio MarchiGabriele Finco
Aug 25, 2009·Journal of Dairy Science·M A G von KeyserlingkD M Weary
Sep 29, 2009·Trends in Neurosciences·David B Reichling, Jon D Levine
Apr 24, 2010·Research in Veterinary Science·K A LeachD C J Main
Jul 14, 2010·The Veterinary Journal·P D Eckersall, R Bell
Dec 22, 2010·British Journal of Anaesthesia·C Voscopoulos, M Lema
Feb 18, 2012·European Journal of Pain : EJP·S BruehlM Chont
Mar 19, 2013·European Journal of Pharmacology·Antti Pertovaara
Jan 30, 2014·American Journal of Veterinary Research·Ruby A MosherChong Wang

Citations

Oct 27, 2018·Journal of Veterinary Research·Alfredo Rosamel RodriguezHedie Almagro Bustamante
Sep 20, 2019·Animals : an Open Access Journal From MDPI·Daniel HerzbergHedie Bustamante
Mar 8, 2020·Animals : an Open Access Journal From MDPI·Rejane Dos Santos SousaEnrico Lippi Ortolani
May 7, 2020·Frontiers in Veterinary Science·Shuaichen LiJiantao Zhang

Related Concepts

Oligofructose
Metazoa
Bos indicus
Cattle Diseases
Lameness, Animal
Oligosaccharides
Pain, Splitting
Metabolic Stress Response
Viral Markers
Beta-Endorphin

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.