Stress and tissue Doppler echocardiographic evidence of effectiveness of myoblast transplantation in patients with ischaemic heart failure

European Journal of Heart Failure
Elena BiaginiPatrick W Serruys

Abstract

There is experimental evidence that transplanting skeletal myoblasts (SM) into the post-infarction myocardial scar improves regional and global left ventricular (LV) function. To evaluate short- and long-term regional and global LV functional effects of percutaneously transplanted SM in patients with ischaemic heart failure. Ten patients (mean age 60+/-10 years, 8 males) with dilated ischaemic cardiomyopathy underwent percutaneous injection of autologous myoblasts. Regional and global LV function was evaluated by 2-dimensional echocardiography and tissue Doppler imaging (TDI) at rest and during low-dose dobutamine infusion to assess contractile reserve. After a baseline examination, sequential follow-ups were performed at 1, 3, and 6 months and 1 year. NYHA functional class decreased from 2.7+/-0.5 to 1.9+/-0.5 (p<0.01) at one year. LV function and volumes at rest remained unchanged while contractile reserve significantly improved during follow-up. At low-dose dobutamine infusion, the peak systolic velocity in the regions of myoblasts injection significantly increased at TDI examination (from 7.7+/-2.1 to 8.6+/-1.8 cm/s, p=0.02); LV ejection fraction improved (from 40+/-9% to 46+/-8%, p<0.0001) and end-systolic volumes decrease...Continue Reading

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Citations

Sep 1, 2008·Journal of Cardiovascular Translational Research·Philippe Menasché
Mar 1, 2009·Journal of Cardiovascular Translational Research·Peter J Psaltis, Stephen G Worthley
Mar 12, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Philippe Menasche
Dec 28, 2007·Cells, Tissues, Organs·Michael Rubart, Loren J Field
Nov 19, 2010·Regenerative Medicine·Shazia DurraniKhawaja Husnain Haider
Jan 12, 2008·Journal of Molecular and Cellular Cardiology·Philippe Menasché
Jul 17, 2007·Comptes rendus biologies·Philippe Menasché
Jul 17, 2007·Progress in Cardiovascular Diseases·Philippe Menasché
Feb 26, 2008·Cell Transplantation·Warren Sherman
Jun 9, 2009·Cell Transplantation·Monika SeidelMaciej Kurpisz
Aug 14, 2012·Innovations : Technology and Techniques in Cardiothoracic and Vascular Surgery·Todd K RosengartRonald G Crystal

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