Stress-Axis Regulation by Vitamin D3 in Multiple Sclerosis

Frontiers in Neurology
Linda RolfJoost Smolders

Abstract

Multiple sclerosis (MS) has been associated with both a poor vitamin D status and hyperactivity of the hypothalamus-pituitary-adrenal (HPA) axis. Since nuclear receptor ligands may regulate each other, we explored the association of vitamin D3 supplements with circadian cortisol levels in a double-blind and placebo-controlled supplementation study. Female patients with relapsing-remitting MS received vitamin D3 supplements (4,000 IU/day; n = 22) or placebo (n = 19) during 16 weeks. Salivary cortisol levels, repeatedly measured during the day, and serum 25(OH)D levels were assessed before (T0) and after (T1) this treatment period. Median 25(OH)D levels at T1 were 139.9 (interquartile range 123.5-161.2) and 74.5 nmol/L (58.6-88.1) in the vitamin D3 and placebo group, respectively (p < 0.001). Comparisons within and between groups showed no differences in area under the curve (AUC) and slope of the cortisol day curve. Although the AUC of the cortisol awakening response (CAR, sampling each 15 min the first hour after awakening) showed a reduction over time in the vitamin D3 group [39.16 nmol/L (27.41-42.07) at T0 to 33.37 nmol/L (26.75-38.08) at T1] compared to the placebo group [33.90 nmol/L (25.92-44.61) at T0 to 35.00 nmol/L (25...Continue Reading

Associated Clinical Trials

Mar 26, 2014·Raymond Hupperts

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Citations

Oct 8, 2019·The International Journal of Neuroscience·Tobore Onojighofia Tobore
Oct 31, 2019·Brain : a Journal of Neurology·Joost SmoldersRaymond Hupperts
Aug 14, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Leoni RolfesSven G Meuth
Nov 7, 2019·CNS Drugs·Joost SmoldersTrygve Holmøy
Dec 18, 2020·Frontiers in Immunology·Justin KillickAnne L Astier

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Methods Mentioned

BETA
contraception

Clinical Trials Mentioned

NCT02096133

Software Mentioned

GraphPad Prism
Sealed Envelope
SPSS
CAR
GraphPad

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