Stress chaperone GRP78/BiP confers chemoresistance to tumor-associated endothelial cells.

Molecular Cancer Research : MCR
Jenilyn J VirreyAmy S Lee

Abstract

The tumor vasculature is essential for tumor growth and survival and is a key target for anticancer therapy. Glioblastoma multiforme, the most malignant form of brain tumor, is highly vascular and contains abnormal vessels, unlike blood vessels in normal brain. Previously, we showed that primary cultures of human brain endothelial cells, derived from blood vessels of malignant glioma tissues (TuBEC), are physiologically and functionally different from endothelial cells derived from nonmalignant brain tissues (BEC) and are substantially more resistant to apoptosis. Resistance of TuBEC to a wide range of current anticancer drugs has significant clinical consequences as it represents a major obstacle toward eradication of residual brain tumor. We report here that the endoplasmic reticulum chaperone GRP78/BiP is generally highly elevated in the vasculature derived from human glioma specimens, both in situ in tissue and in vitro in primary cell cultures, compared with minimal GRP78 expression in normal brain tissues and blood vessels. Interestingly, TuBEC constitutively overexpress GRP78 without concomitant induction of other major unfolded protein response targets. Resistance of TuBEC to chemotherapeutic agents such as CPT-11, etop...Continue Reading

References

Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·C JamoraA S Lee
Dec 31, 1997·The Journal of Biological Chemistry·J C Morris, K Mensa-Wilmot
Aug 16, 2001·Trends in Biochemical Sciences·A S Lee
Jun 5, 2003·Nature Reviews. Cancer·Gabriele Bergers, Laura E Benjamin
Sep 4, 2003·The Cancer Journal·Ian F Parney, Susan M Chang
Nov 19, 2003·Current Opinion in Oncology·R Nagasubramanian, M Eileen Dolan
Sep 2, 2004·Journal of the National Cancer Institute·Hae-Ryong ParkKazuo Shin-ya
Sep 30, 2004·The Journal of Laboratory and Clinical Medicine·Ayumi HidaKatsumi Eguchi
Dec 2, 2004·Nature Reviews. Cancer·Yanjun Ma, Linda M Hendershot
Apr 5, 2005·Methods : a Companion to Methods in Enzymology·Amy S Lee
Feb 14, 2006·Current Molecular Medicine·Jianze Li, Amy S Lee
Feb 13, 2007·Experimental Cell Research·Christiana CharalambousFlorence M Hofman
Mar 22, 2007·Molecular Pharmaceutics·Ying LiuKim D Janda

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Citations

Dec 22, 2009·The Journal of Biological Chemistry·Jane L ArmstrongChristopher P F Redfern
Mar 9, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·T WinderH-J Lenz
Apr 4, 2014·Biological & Pharmaceutical Bulletin·Kazushi MatsumuraMitsuru Hashida
Dec 2, 2014·Neurosurgical Focus·Encouse B GoldenThomas C Chen
Jul 12, 2011·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Wen-Chin WengHsinyu Lee
Sep 25, 2012·Biochemical Pharmacology·Axel H Schönthal
Aug 1, 2012·Pulmonary Pharmacology & Therapeutics·Steven G Kelsen
Mar 20, 2012·Biochimica Et Biophysica Acta·Zongwei Li, Zhuoyu Li
Oct 20, 2009·European Journal of Pharmacology·Sandra J M HealyAfshin Samali
Jun 2, 2009·Seminars in Cancer Biology·Liangru ContoisPeter C Brooks
May 28, 2010·Journal of Cellular Biochemistry·Lu-Hua Zhang, Xiang Zhang
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Eunjung LeeAmy S Lee
Mar 16, 2013·Cell Biology International·Marco Fidel AvilaGeorge E Barreto
Jan 5, 2011·Journal of Cellular and Molecular Medicine·Xiangming SunYangfu Jiang
Oct 12, 2012·Annals of the New York Academy of Sciences·Dong Hoon SuhYong Sang Song
Jun 8, 2012·Advanced Materials·Timothy R PearceEfrosini Kokkoli
Aug 19, 2015·Cell Metabolism·François Binet, Przemyslaw Sapieha
Mar 14, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Veli KilincSedat Gulten
Mar 23, 2011·Biochimica Et Biophysica Acta·E FarmakiH Kiaris

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