Stress cytokines: pivotal proteins in immune regulatory networks; Opinion

Current Opinion in Immunology
Gabriel S PanayiBrian Henderson

Abstract

Stress proteins have three immunological regulatory functions: within the cell, on the cell membrane as signalling receptors, and in the extracellular environment as stress cytokines. They can activate the immune system by providing danger signals or they may downregulate immune and inflammatory responses. In addition, they can modulate immune responses by acting as chaperones for antigenic peptides while they themselves are processed and presented to T cells as self-peptides. We predict that the exploitation of the downregulatory properties of stress cytokines will have therapeutic applications in the treatment of human chronic inflammatory diseases, such as rheumatoid arthritis.

References

Nov 30, 1994·Experientia·T J Hall
Feb 24, 2001·Cell Stress & Chaperones·W van EdenR van der Zee
Feb 12, 2002·The Journal of Biological Chemistry·Alexzander AseaStuart K Calderwood
Mar 9, 2002·Science·F Ulrich Hartl, Manajit Hayer-Hartl
Mar 26, 2002·The Journal of Biological Chemistry·Ramunas M VabulasHansjorg Schild
Oct 2, 2002·Immunity·Yves DelnestePascale Jeannin
Oct 3, 2002·The Journal of Cell Biology·Thalia BeckerFelix Wieland
Mar 26, 2003·Cell Stress & Chaperones·Maria MaguireBrian Henderson
Mar 26, 2003·Infection and Immunity·Nemani V PrasadaraoSunil K Sukumaran
Apr 17, 2003·Developmental and Comparative Immunology·Jacques Robert
Mar 6, 2004·American Journal of Physiology. Cell Physiology·Min-Fu Tsan, Baochong Gao

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Citations

Sep 21, 2010·Inflammation·Xinjing LuoXianzhong Xiao
Jan 5, 2012·Cell Stress & Chaperones·Brian Henderson, A Graham Pockley
Jun 23, 2006·Infection and Immunity·Brian HendersonAnthony R M Coates
May 24, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Monika Moll, Jasmin B Kuemmerle-Deschner
Oct 11, 2007·The American Naturalist·Kevin PauwelsLuc De Meester
Sep 12, 2007·Trends in Immunology·Anna Rubartelli, Michael T Lotze
Oct 29, 2005·Tuberculosis·Rohini QamraBrian Henderson
Mar 1, 2012·Neurotoxicology·Evelyn Tiffany-Castiglioni, Yongchang Qian
Jan 25, 2006·Autoimmunity Reviews·G S Panayi, V M Corrigall
Jan 10, 2008·Trends in Biochemical Sciences·Alan Graham PockleyStuart K Calderwood
May 28, 2013·International Journal of Molecular Sciences·Regina P MarkusMarco Antonio Pires-Lapa
May 17, 2018·Cell Stress & Chaperones·Frank KaiserLuigi Nibali
Dec 6, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Adrienne L EdkinsGregory L Blatch
Jan 9, 2014·Journal of Leukocyte Biology·Liliana Jaso-FriedmannDonald L Evans
Aug 2, 2007·Journal of Immunotherapy·Michael B AtkinsLouis M Weiner
Mar 24, 2005·Psychosomatic Medicine·Sibylle KlosterhalfenPaul Enck
Mar 24, 2005·Cytometry. Part B, Clinical Cytometry·Silverio SbranaAldo Clerico
Jan 19, 2006·Journal of Medical Virology·E EspigaresR Gálvez
Jun 16, 2011·Clinical and Experimental Immunology·A M ShieldsV M Corrigall
Jun 13, 2020·Frontiers in Physiology·Russell G RogersAhmed G Ibrahim
Jun 30, 2010·The Annals of Otology, Rhinology, and Laryngology·Nicole Y K LiKatherine Verdolini Abbott
Dec 7, 2019·Journal of Burn Care & Research : Official Publication of the American Burn Association·Li-Wu QianKai P Leung
Jul 28, 2020·Circulation Research·Na Li, Bianca J J M Brundel
Jul 11, 2006·Immunology Letters·Emmanuel KarouzakisSteffen Gay

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