PMID: 9526828Apr 4, 1998Paper

Stress, diet and alcohol-induced oxidative gastrointestinal mucosal injury in rats and protection by bismuth subsalicylate

Journal of Applied Toxicology : JAT
D BagchiS J Stohs

Abstract

Oxygen free radicals are implicated in the pathogenesis of stress and food/alcohol-induced gastrointestinal injury. We have investigated the effects of restraint stress, spicy food diet, high-fat diet and 40% ethanol on the enhanced production of reactive oxygen species, including superoxide anion and hydroxyl radicals, and on DNA fragmentation, lipid peroxidation and membrane microviscosity (indices of oxidative tissue damage) in gastric and intestinal mucosa of Sprague-Dawley rats. Furthermore, the protective ability of bismuth subsalicylate (BSS; 15 mg kg(-1) was determined against the gastrointestinal mucosal injury induced by these stressors. Animals on the high-fat diet consumed 31% more food as compared to other animals. Animals on the spicy food diet consumed ca. 23% more water as compared to control animals, and the high-fat diet animals consumed 17% less water. Restraint stress provided greater injury to both gastric and intestinal mucosa as compared to other stressors. Restraint stress, spicy food diet, high-fat diet and ethanol increased superoxide anion production by 10.0-, 4.3-, 5.7- and 4.8-fold, respectively, in the gastric mucosa, and by 10.4-, 5.3-, 7.0- and 5.5-fold in the intestinal mucosa. Exposure to restr...Continue Reading

Citations

Jul 9, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·V OjettiA Gasbarrini
Jun 10, 2000·Alimentary Pharmacology & Therapeutics·K G MandelH I Jacoby
Oct 16, 2008·World Journal of Gastroenterology : WJG·Jin-Shui PanJian-Lin Ren
Jan 15, 2013·Clinics and Research in Hepatology and Gastroenterology·Bilal ErgülSeyfettin Köklü
Jan 13, 2016·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Atsuki TsuruyaToru Nakayama
Aug 2, 2011·Journal of Ethnopharmacology·Z A ZakariaM Z Salleh
Jun 2, 2009·Fitoterapia·Bárbara MayerMaria Consuelo Andrade Marques
Sep 22, 2007·Journal of Ethnopharmacology·B BerenguerM J Martín-Calero
Oct 3, 2006·BioFactors·Mahesh ThirunavukkarasuNilanjana Maulik
Sep 4, 2004·Biochemical Pharmacology·Nandita Shangari, Peter J O'Brien
Oct 11, 2015·Pharmaceutical Biology·Zainul Amiruddin ZakariaMohd Zaki Salleh
Oct 30, 2007·Journal of Applied Toxicology : JAT·Ramazan AmanvermezCemil Celik
Jan 1, 2006·Toxicology Mechanisms and Methods·M A SharaD Bagchi
Mar 19, 2014·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Erik SjögrenPeter Langguth
Nov 18, 2008·Chemico-biological Interactions·Rhea MehtaPeter J O'Brien
Aug 4, 2016·Journal of Ethnopharmacology·David Raj ChellappanPemiah Brindha
Jul 17, 2010·Human & Experimental Toxicology·C S MotaL F Bauermann
Sep 12, 2015·Human & Experimental Toxicology·B T RovaniL de Freitas Bauermann
Jul 4, 2002·The American Journal of Gastroenterology·Nicole CarlsonMamoun Younes
Nov 23, 2017·Clinical and Experimental Pharmacology & Physiology·Berna KarakoyunGöksel Şener
Jun 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·A LaurilaJ L Witztum
Nov 16, 2019·Digestive Diseases and Sciences·Rieko MukaiYoshito Itoh
Dec 13, 2019·Oxidative Medicine and Cellular Longevity·Lady D K T PrazeresAlmir G Wanderley
Apr 9, 2009·Acta Biochimica Et Biophysica Sinica·Wei ZhaoGuohui Fu
Aug 17, 2000·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·H YamamotoY Yamaoka
Sep 26, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marco SiechMax G Bachem
Feb 20, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Wei ZhongZhanxiang Zhou
Sep 26, 2009·Toxicology Mechanisms and Methods·A V KrishnarajuG Trimurtulu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.