'Stress' distributions inside intervertebral discs. The effects of age and degeneration

The Journal of Bone and Joint Surgery. British Volume
M A AdamsP Dolan

Abstract

We investigated the distribution of compressive 'stress' within cadaver intervertebral discs, using a pressure transducer mounted in a 1.3 mm diameter needle. The needle was pulled along the midsagittal diameter of a lumbar disc with the face of the transducer either vertical or horizontal while the disc was subjected to a constant compressive force. The resulting 'stress profiles' were analysed in order to characterise the distribution of vertical and horizontal compressive stress within each disc. A total of 87 discs from subjects aged between 16 and 87 years was examined. Our results showed that age-related degenerative changes reduced the diameter of the central hydrostatic region of each disc (the 'functional nucleus') by approximately 50%, and the pressure within this region fell by 30%. The width of the functional annulus increased by 80% and the height of compressive 'stress peaks' within it by 160%. The effects of age and degeneration were greater at L4/L5 than at L2/L3, and the posterior annulus was affected more than the anterior. Age and degeneration were themselves closely related, but the stage of degeneration had the greater effect on stress distributions. We suggest that structural changes within the annulus and...Continue Reading

Citations

Sep 21, 2013·Rheumatology·Fengjuan LvKenneth M C Cheung
Jan 3, 2014·BioMed Research International·Bao-Qing PeiShu-Qin Wu
Oct 13, 2011·Advances in Orthopedics·Ghassan S SkafMukbil H Hourani
Aug 2, 2014·Journal of Neurosurgery. Spine·Brian D StemperDennis J Maiman
Jun 30, 2012·Advances in Orthopedics·V PalepuV K Goel
Jul 13, 2006·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Klaus John SchnakeFrank Kandziora
Aug 30, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Yue-Hui ZhangLi-Yang Dai
Sep 17, 2008·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michael N TzermiadianosAvinash G Patwardhan
Jan 9, 2009·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Mark DriscollStefan Parent
Aug 30, 2008·Regenerative Medicine·N S KalsonJ A Hoyland
Nov 1, 2003·The Spine Journal : Official Journal of the North American Spine Society·Raj D RaoSanti Rao
May 27, 2005·Neurosurgical Focus·Michael D MartinDavid G Malone
Aug 10, 2000·Journal of Veterinary Medicine. A, Physiology, Pathology, Clinical Medicine·V F Jensen, A K Ersbøll
Feb 8, 2008·Journal of Occupational Rehabilitation·Jennifer PyntJoy Higgs
Mar 23, 1999·Journal of the American Academy of Nurse Practitioners·R L Buti
Jan 24, 2006·Journal of the American Veterinary Medical Association·Gwendolyn J LevineGeoffrey T Fosgate
Nov 13, 2001·American Journal of Veterinary Research·R A MitchellD McNally
Jan 14, 2011·Computer Methods in Biomechanics and Biomedical Engineering·Ugur M Ayturk, Christian M Puttlitz
Jul 17, 2009·Journal of Biomechanical Engineering·Oliver M O'ReillyJeffrey C Lotz
Oct 5, 2010·Journal of Biomechanical Engineering·Ugur M AyturkChristian M Puttlitz
May 28, 2013·The Spine Journal : Official Journal of the North American Spine Society·John M PopovichKornelia Kulig
Feb 2, 2013·The Spine Journal : Official Journal of the North American Spine Society·James C IatridisMichelle S Gupta
Nov 28, 2015·The Spine Journal : Official Journal of the North American Spine Society·Alon LaiJames C Iatridis
Jul 19, 2011·Medical Engineering & Physics·T CercielloR Allen
Apr 21, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Lachlan J Smith, Dawn M Elliott
Feb 23, 2011·Medical Hypotheses·Xin-Long MaChao Han
Sep 8, 2010·Journal of Biomechanics·Aaron J FieldsTony M Keaveny

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