Stress Erythropoiesis is a Key Inflammatory Response.

Cells
Robert F PaulsonYuanting Chen

Abstract

Bone marrow medullary erythropoiesis is primarily homeostatic. It produces new erythrocytes at a constant rate, which is balanced by the turnover of senescent erythrocytes by macrophages in the spleen. Despite the enormous capacity of the bone marrow to produce erythrocytes, there are times when it is unable to keep pace with erythroid demand. At these times stress erythropoiesis predominates. Stress erythropoiesis generates a large bolus of new erythrocytes to maintain homeostasis until steady state erythropoiesis can resume. In this review, we outline the mechanistic differences between stress erythropoiesis and steady state erythropoiesis and show that their responses to inflammation are complementary. We propose a new hypothesis that stress erythropoiesis is induced by inflammation and plays a key role in maintaining erythroid homeostasis during inflammatory responses.

References

Jan 1, 1976·American Journal of Hematology·H Hara, M Ogawa
Jul 1, 1976·British Journal of Haematology·R J Cole, T Regan
Jul 1, 1986·British Journal of Haematology·R S WeinbergB P Alter
Oct 1, 1972·British Journal of Haematology·R J ColeR G Tarbutt
Jun 1, 1973·Journal of Cellular Physiology·C J GregoryJ E Till
Mar 1, 1969·Genetics·D L ColemanE Y Levin
Nov 14, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R L Jurado
Oct 26, 1999·Cell Structure and Function·M Obinata, N Yanai
Dec 2, 1999·Genes & Development·A BauerH Beug
Sep 12, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katia La FerlaThomas Hellwig-Bürgel
Nov 9, 2002·Experimental Hematology·Weiguo XiaoKen ichi Sawada
Jan 11, 2003·Blood·Susanne LudwiczekGünter Weiss
Dec 14, 2004·Blood·Laurie E LenoxRobert F Paulson
Dec 7, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Shailaja HegdeRobert F Paulson
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ke ChenNarla Mohandas
Oct 19, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Amy JacksonStephen J McSorley
Mar 5, 2011·Current Opinion in Hematology·Robert F PaulsonDai-Chen Wu
May 11, 2011·The Journal of Experimental Medicine·Mark P BoldinDavid Baltimore
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jimmy L ZhaoDavid Baltimore
Feb 7, 2012·Biochimica Et Biophysica Acta·Tomas Ganz, Elizabeta Nemeth
Jun 21, 2012·Critical Care Clinics·Devina Prakash

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Citations

Jan 20, 2021·Journal of Leukocyte Biology·Debopam Ghosh, Jason S Stumhofer
Feb 3, 2021·International Journal of Environmental Research and Public Health·Simona PisantiRosanna Martinelli
Oct 30, 2020·Scientific Reports·Ángela SánchezSusana Alemany
May 25, 2021·Immunological Reviews·Alicia BellomoMarc Bajénoff
May 28, 2021·Physiological Reports·Yasminye D PettwayJennifer S Pollock
Jun 26, 2021·Pharmacology & Therapeutics·Tomasz M GrzywaJakub Golab

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