PMID: 8591811Mar 1, 1995Paper

Stress experiments as a means of investigating age-specific mortality in Drosophila melanogaster

Experimental Gerontology
A A KhazaeliJ W Curtsinger

Abstract

Age-specific mortality rates level off at older ages in genetically homogeneous experimental populations of Drosophila. Here we describe an experiment that is informative about the causes of mortality rate changes. By applying a brief, nondebilitating stress that increases mortality early in life and then observing subsequent mortality trajectories, it is possible to determine whether populations are heterogeneous for factors influencing mortality. We show that 24-h exposure to a desiccating air flow causes a spike and then a decrease in mortality rates in experimental populations compared to controls. If there is no stress-induced enhancement of vitality, then the results demonstrate the existence of heterogeneity for mortality rates in genetically homogeneous populations.

References

Sep 1, 1995·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A A KhazaeliJ W Curtsinger
Jan 6, 1994·Nature·K A Hughes, B Charlesworth
Nov 1, 1993·Experimental Gerontology·H H FukuiJ W Curtsinger
Jun 11, 1993·Science·J W Vaupel, J R Carey
Jan 1, 1987·Mathematical Population Studies·J W VaupelK G Manton

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Citations

Dec 23, 1998·Mechanisms of Ageing and Development·A A KhazaeliJ W Curtsinger
Dec 29, 1998·Experimental Gerontology·J W Curtsinger, A Khazaeli
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·G J LithgowT E Johnson
Jan 12, 2012·Rejuvenation Research·Parvin ShahrestaniMichael R Rose
Dec 29, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M R Rose, L D Mueller
Feb 13, 2016·Journal of Insect Physiology·Luciana Mercedes Pujol-LereisLuis Alberto Quesada-Allué
Nov 20, 2009·Experimental Gerontology·Shuguang LiShi V Liu
Dec 18, 2001·Journal of Theoretical Biology·L A Gavrilov, N S Gavrilova
Oct 1, 1996·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G J Lithgow
Feb 18, 2009·Evolution; International Journal of Organic Evolution·Michael Gurven, Andrew Fenelon
Apr 1, 1998·Evolution; International Journal of Organic Evolution·Scott D Pletcher, James W Curtsinger

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