Stress granules safeguard against MAPK signaling hyperactivation by sequestering PKC/Pck2: new findings and perspectives.

Current Genetics
Reiko Sugiura

Abstract

Stress granule (SG) assembly is a conserved cellular strategy that copes with stress-related damage and promotes cell survival. SGs form through a process of liquid-liquid phase separation. Cellular signaling also appears to employ SG assembly as a mechanism for controlling cell survival and cell death by spatial compartmentalization of signal-transducing factors. While several lines of evidence highlight the importance of SGs as signaling hubs, where protein components of signaling pathways can be temporarily sequestered, shielded from the cytoplasm, the regulation and physiological significance of SGs in this aspect remain largely obscure. A recent study of the heat-shock response in the fission yeast Schizosaaccharomyces pombe provides an unexpected answer to this question. Recently, we demonstrated that the PKC orthologue Pck2 in fission yeast translocates into SGs through phase separation in a PKC kinase activity-dependent manner upon high-heat stress (HHS). Importantly, the downstream MAPK Pmk1 promotes Pck2 recruitment into SGs, which intercepts MAPK hyperactivation and cell death, thus posing SGs as a negative feedback circuit in controlling MAPK signaling. Intriguingly, HHS, but not modest-heat stress targets Pck2 to S...Continue Reading

References

Nov 21, 2002·Biochemical Society Transactions·N Kedersha, P Anderson
Sep 21, 2007·Molecular Biology of the Cell·Hirofumi TakadaReiko Sugiura
Oct 10, 2007·Methods in Enzymology·Nancy Kedersha, Paul Anderson
Aug 23, 2008·IUBMB Life·Lisa L Gallegos, Alexandra C Newton
Oct 7, 2008·Nature Cell Biology·Kyoko ArimotoMutsuhiro Takekawa
May 23, 2009·Nature Reviews. Molecular Cell Biology·Paul Anderson, Nancy Kedersha
Aug 25, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Gloria Gutiérrez-VenegasJosé Antonio Méndez-Mejía
Nov 26, 2009·American Journal of Physiology. Endocrinology and Metabolism·Alexandra C Newton
Nov 26, 2010·RNA·Daniel Nilsson, Per Sunnerhagen
Oct 1, 2011·Wiley Interdisciplinary Reviews. RNA·Takbum Ohn, Paul Anderson
Jun 26, 2012·Molecular Cell·Terunao Takahara, Tatsuya Maeda
Sep 14, 2013·Trends in Biochemical Sciences·Nancy KedershaPaul Anderson
Jul 6, 2014·Traffic·Hicham Mahboubi, Ursula Stochaj
Dec 23, 2014·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Mari HigaReiko Sugiura
Apr 4, 2015·Biochimica Et Biophysica Acta·Hicham MahboubiUrsula Stochaj
Feb 8, 2016·Current Genetics·R Nostramo, P K Herman
Dec 17, 2016·Cell·Elda Grabocka, Dafna Bar-Sagi
Sep 25, 2017·Science·Yongdae Shin, Clifford P Brangwynne
Jan 31, 2018·Biochemistry·Yang LuoSarah A Slavoff
Jun 20, 2018·Nature Immunology·Wan-Lin LoArthur Weiss
Dec 28, 2018·The Journal of Biological Chemistry·Mario Hofweber, Dorothee Dormann
Mar 30, 2019·Life Science Alliance·Alexander Martin HeberleKathrin Thedieck
Jul 14, 2019·British Journal of Pharmacology·Xiaomeng GaoJi Cao
Aug 11, 2019·Nature Communications·Jenifer E ShattuckEric D Ross
Aug 23, 2019·Nature·Maria HondeleKarsten Weis
Aug 20, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Fei WangCheng Huang
Sep 3, 2020·Journal of Cell Science·Claire L RiggsPaul Anderson

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