Stress in biology and medicine, role in aging

Pathologie-biologie
L Robert, J Labat-Robert

Abstract

In this review, we present a short description of the history of stress in the medical literature followed by a recapitulation of its mechanisms, from the cellular to the organismal level and its role in aging. The medical importance of stress was first taken up as a subject of experimental medicine by physiologists, starting from Claude Bernard's concept of the stability of the "milieu intérieur", altered by stress, followed by others, culminating recently by the elucidation of its mechanisms at the cellular and molecular level. These studies showed that oxidative stress is one of the most important and most frequent form of biological aggression. Its accumulation over time is important for the burnout syndrome and for neuronal aging. There is however a positive side to it also, redox signaling plays an important role in the functional coordination of cellular activities. These mechanisms, still to be more completely evaluated, have to be taken in account for planning efficient protective therapeutic interventions.

References

Nov 24, 2001·Respiration Physiology·A P Wickens
Sep 19, 2002·The Journal of Biological Chemistry·Julie St-PierreMartin D Brand
Jun 17, 1950·British Medical Journal·H SELYE
Apr 19, 2008·Cold Spring Harbor Symposia on Quantitative Biology·L Guarente
Sep 10, 2011·PloS One·Magdalene K MontgomeryWilliam A Buttemer
Aug 14, 2012·Trends in Cell Biology·Jay H ChungJason R B Dyck
Apr 4, 2014·Nature·Suzanne Wolff, Andrew Dillin
Oct 25, 2014·Burnout Research·Allison SquiresWalter Sermeus

❮ Previous
Next ❯

Citations

Oct 22, 2016·Archives of Physiology and Biochemistry·Sandeep SinghSyed Ibrahim Rizvi
Apr 4, 2020·Antioxidants & Redox Signaling·Aleksandra Mladenovic DjordjevicEfstathios S Gonos
Sep 10, 2019·Archives of Physiology and Biochemistry·Sandeep SinghSyed Ibrahim Rizvi
Dec 7, 2017·BioFactors·Yi-Rong LiChi-Chien Lin
Jan 20, 2021·International Journal of Occupational Safety and Ergonomics : JOSE·Jamal BiganehMajid Bagheri Hosseinabadi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.