PMID: 11904621Mar 21, 2002Paper

Stress in pregnancy: a new Wistar rat model for human preeclampsia

American Journal of Obstetrics and Gynecology
Nilton H TakiutiMarcelo Zugaib

Abstract

Our study evaluated the effects of chronic and/or acute stress on pregnant and nonpregnant female rats. The rats were exposed to the sonic stimulus associated with overpopulation between days 7 and 14 of pregnancy. The rats were immobilized 2 days before the vascular reactivity experiments. In 14-day pregnant rats, chronic stress led to lower weight, increased adrenal weight, lower endothelium-derived relaxing factor release, and lower fetal weight. In 20-day pregnant rats, chronic stress caused decreased weight gain, higher blood pressure, increased vasomotility and proteinuria, lower endothelium-derived relaxing factor release, and lower fetal weight. In the 20-day pregnant group, the higher adrenal weight resulted in higher blood pressure, lower vascular relaxation, and lower average fetal weight. A greater number of fetuses had higher adrenal weight, higher blood pressure, and lower vascular relaxation. The alterations found in the rats were similar to those that occur in human preeclampsia. Therefore, we propose a new animal model for human preeclampsia.

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Citations

Nov 6, 2004·Seminars in Nephrology·Eduardo PodjarnyChris Baylis
Apr 19, 2011·Placenta·F P McCarthyS K Walsh
Jul 16, 2013·American Journal of Obstetrics and Gynecology·Yunxian YuXiaobin Wang
Jun 19, 2014·Maternal and Child Health Journal·Vanessa J Hux, James M Roberts
Jun 10, 2008·European Journal of Pharmacology·Nergiz Hacer TurgutBaris Karadas
Sep 25, 2017·Endocrine Reviews·Luba SominskySarah J Spencer
Nov 3, 2017·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Dongxin ZhangDuyun Ye
Jul 12, 2012·Reproduction, Fertility, and Development·Isis Paloppi CorrêaMarcelo Zugaib
Jul 10, 2003·Clinical Biochemistry·Abdelaziz KharfiJean-Claude Forest

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