Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases

Frontiers in Neuroscience
Fan JieBingjin Li

Abstract

The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala.

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Citations

Apr 6, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Verena Theis, Carsten Theiss
Jan 11, 2020·Frontiers in Physiology·Geoffrey A HeadCindy Gueguen
Apr 17, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Wen YuYu-Mei Wu
Jul 28, 2019·Frontiers in Neuroendocrinology·Josep Moreno-Rius
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Oct 7, 2020·Biochemical and Biophysical Research Communications·Qian XiaoJie Tu
Mar 23, 2021·Frontiers in Behavioral Neuroscience·Taylor A McCorkleRamesh Raghupathi
Oct 10, 2020·Current Biology : CB·Zhe ZhaoGiovanni Marsicano
Nov 17, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Zhaoxin LiChen Huang

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