Stress-Induced Anxiety- and Depressive-Like Phenotype Associated with Transient Reduction in Neurogenesis in Adult Nestin-CreERT2/Diphtheria Toxin Fragment A Transgenic Mice

PloS One
Sanghee YunAmelia J Eisch

Abstract

Depression and anxiety involve hippocampal dysfunction, but the specific relationship between these mood disorders and adult hippocampal dentate gyrus neurogenesis remains unclear. In both humans with MDD and rodent models of depression, administration of antidepressants increases DG progenitor and granule cell number, yet rodents with induced ablation of DG neurogenesis typically do not demonstrate depressive- or anxiety-like behaviors. The conflicting data may be explained by the varied duration and degree to which adult neurogenesis is reduced in different rodent neurogenesis ablation models. In order to test this hypothesis we examined how a transient-rather than permanent-inducible reduction in neurogenesis would alter depressive- and anxiety-like behaviors. Transgenic Nestin-CreERT2/floxed diphtheria toxin fragment A (DTA) mice (Cre+DTA+) and littermates (Cre+DTA-; control) were given tamoxifen (TAM) to induce recombination and decrease nestin-expressing stem cells and their progeny. The decreased neurogenesis was transient: 12 days post-TAM Cre+DTA+ mice had fewer DG proliferating Ki67+ cells and fewer DCX+ neuroblasts/immature neurons relative to control, but 30 days post-TAM Cre+DTA+ mice had the same DCX+ cell number ...Continue Reading

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Citations

Apr 18, 2018·Hippocampus·Rose-Marie KarlssonHeather A Cameron
Jan 31, 2017·ELife·Elena W AdlafLinda Overstreet-Wadiche
Oct 1, 2019·Anatomia, histologia, embryologia·Louise C Abbott, Fikru Nigussie
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Apr 18, 2019·Molecular Neurobiology·Kelly N H NudelmanAndrew J Saykin
Dec 12, 2019·Frontiers in Pharmacology·Simona Federica SpampinatoMariagrazia Grilli
Oct 22, 2020·ERJ Open Research·Caroline-Aleksi Olsson MägiBjörn Nordlund
May 27, 2020·Mini Reviews in Medicinal Chemistry·Sze Yuen LewKah Hui Wong
Jul 25, 2021·International Journal of Molecular Sciences·Julia LeschikAntonietta Gentile

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Methods Mentioned

BETA
PCR
transgenic
dissection

Software Mentioned

SPSS
Ethovision

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