Stress-induced cell-cycle activation in Tip60 haploinsufficient adult cardiomyocytes.

PloS One
Joseph B FisherJohn Lough

Abstract

Tat-interactive protein 60 (Tip60) is a member of the MYST family of histone acetyltransferases. Studies using cultured cells have shown that Tip60 has various functions including DNA repair, apoptosis and cell-cycle regulation. We globally ablated the Tip60 gene (Htatip), observing that Tip60-null embryos die at the blastocyst stage (Hu et al. Dev.Dyn.238:2912;2009). Although adult heterozygous (Tip60(+/-)) mice reproduce normally without a haploinsufficient phenotype, stress caused by Myc over-expression induced B-cell lymphoma in Tip60(+/-) adults, suggesting that Tip60 is a tumor suppressor (Gorrini et al. Nature 448:1063;2007). These findings prompted assessment of whether Tip60, alternative splicing of which generates two predominant isoforms termed Tip60α and Tip60β, functions to suppress the cell-cycle in adult cardiomyocytes. Western blotting revealed that Tip60α is the predominant Tip60 isoprotein in the embryonic heart, transitioning at neonatal stages to Tip60β, which is the only isoprotein in the adult heart wherein it is highly enriched. Over-expression of Tip60β, but not Tip60α, inhibited cell proliferation in NIH3T3 cells; and, Tip60-haploinsufficient cultured neonatal cardiomyocytes exhibited increased cell-cyc...Continue Reading

References

Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S IzumoV Mahdavi
Jan 10, 1998·The Journal of Biological Chemistry·T Yamamoto, M Horikoshi
Jul 22, 1998·Circulation Research·M H Soonpaa, L J Field
Mar 23, 2001·The Journal of Biological Chemistry·H J LeeK V Kandror
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·H OhM D Schneider
Mar 14, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John W Lough
Aug 18, 2004·The Journal of Biological Chemistry·Gaëlle LegubeDidier Trouche
May 5, 2005·Genes & Development·Felix B EngelMark T Keating
Jun 14, 2005·Cardiovascular Research·Patricia Cabeza MeckertRubén Laguens
Jun 30, 2005·American Journal of Physiology. Renal Physiology·Katarina MuckovaAlice M Sheridan
Aug 17, 2005·The Journal of Biological Chemistry·Matthew R Hass, Bruce A Yankner
Apr 7, 2006·The Journal of Biological Chemistry·Min-Su KimJohn Lough
May 16, 2006·The International Journal of Biochemistry & Cell Biology·Vasileia SapountziCraig N Robson
Dec 26, 2006·Molecular Cell·Sandrine TytecaDidier Trouche
Dec 26, 2006·Molecular Cell·Stephen M SykesSteven B McMahon
Jul 3, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Indroneal BanerjeeTroy A Baudino
Aug 3, 2007·Genes & Development·Nicolas GévryLuc Gaudreau
May 20, 2008·Cell·Yi TangWei Gu
Jan 15, 2009·Apoptosis : an International Journal on Programmed Cell Death·Youngil Lee, Asa B Gustafsson
Apr 3, 2009·Pediatric Cardiology·Wuqiang ZhuLoren J Field
Apr 4, 2009·Science·Olaf BergmannJonas Frisén
Sep 2, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Anne K Voss, Tim Thomas
Oct 21, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yaofei HuJohn Lough
Sep 15, 2010·PloS One·Yiqiang ZhangEduardo Marbán
Nov 20, 2010·Circulation Research·Jan KajsturaPiero Anversa
Feb 18, 2011·Experimental Cell Research·AndreAna N PeñaOlivia M Pereira-Smith
Feb 26, 2011·Science·Enzo R PorrelloHesham A Sadek
Aug 10, 2011·The Journal of Cell Biology·Patima SdekW Robb Maclellan

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Citations

May 13, 2014·Cell and Tissue Research·Thomas NührenbergLutz Hein
Mar 14, 2013·Science Signaling·Jean RosenbaumPedro M Matias
Feb 27, 2016·Cell Death and Differentiation·C BassiC Gorrini
Jan 11, 2020·Frontiers in Cell and Developmental Biology·Brian Lam, Emilie Roudier
Feb 18, 2021·Pharmaceutical Patent Analyst·Hermann Am Mucke
Feb 21, 2021·Journal of Molecular and Cellular Cardiology·Xinrui WangJohn W Lough

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Methods Mentioned

BETA
genotyping
transgenic
Transfection
acetylates
acetylation

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