Stress-induced changes in regional monoamine metabolism and behavior in rats

Physiology & Behavior
S Sudha, N Pradhan

Abstract

Groups of adult, male, Sprague-Dawley rats were subjected to either restraint at room temperature or cold restraint at 4 +/- 1 degree C for 2 h. Spontaneous motility, measured immediately after the stress, was decreased and defecation scores were increased in the cold restraint group but not in the restraint group. The rats were then sacrificed and prefrontal cortex, nucleus accumbens, and striatum dissected out. The levels of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were measured in these areas by high performance liquid chromatography (HPLC) with electrochemical detection. DA levels were decreased in the prefrontal cortex (-68%), nucleus accumbens (-40%), and striatum (-76%) of the cold restraint group when compared to the controls. DA levels were decreased only in the prefrontal cortex of the restraint rats (-31%) when compared to the controls. The cold restraint group also had increased levels of DOPAC in the prefrontal cortex (+66%) and nucleus accumbens (+65%) and increased levels of HVA in the prefrontal cortex (+43%) when compared to the control group. Our results therefore indicate that cold restraint activates DA metabolism i...Continue Reading

References

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Jul 1, 1991·Physiology & Behavior·N Pradhan, S Arunasmitha
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Citations

Sep 8, 2000·Bulletin of Experimental Biology and Medicine·S B SeredeninB A Badyshtov
Aug 23, 2002·Behavioural Brain Research·Den'etsu Sutoo, Kayo Akiyama
Apr 2, 2008·Behavioural Brain Research·Sara Eugenia Cruz-MoralesRoberto Domínguez
Feb 8, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Leo SherJ John Mann
Feb 16, 2000·Molecular Psychiatry·L PaniG L Gessa

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