PMID: 9537679Apr 16, 1998Paper

Stress-induced cross-sensitization to cocaine: effect of adrenalectomy and corticosterone after short- and long-term withdrawal

Psychopharmacology
B M PrasadB A Sorg

Abstract

We have recently shown that adrenalectomy (ADX) in rats blocks the appearance of cocaine-induced sensitization when this behavioral response is tested at early withdrawal times (1-2 days), but not after later withdrawal from cocaine (12 days). To determine if a similar phenomenon occurred with stress-induced sensitization, male Sprague-Dawley rats were given a sham ADX, ADX surgery, or ADX plus s.c. implanted corticosterone (CORT) pellets (CORT 12.5% pellets or CORT 50% pellets). A fifth group was given ADX surgery, but CORT 50% pellets were implanted after repeated stress treatment. One week after surgery, each group was divided into two additional groups, naive and stress. Naive animals remained unhandled, while stress rats were given a variety of daily stressors administered twice per day for 6 consecutive days. One day after the last stress, rats were given a saline injection followed by a cocaine injection (15 mg/kg, i.p.) the next day, and locomotor activity was monitored (early withdrawal). Two weeks after the last stress, the locomotor responses to an additional saline and cocaine injection were monitored (late withdrawal). At early withdrawal, no significant sensitization occurred for horizontal activity, but cross-sen...Continue Reading

Citations

Dec 22, 2007·Psychopharmacology·Herbert E CovingtonKlaus A Miczek
Nov 26, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nick E Goeders
Feb 26, 2004·Neuroscience·L Matuszewich, B K Yamamoto
Jul 20, 2002·Physiology & Behavior·Monika TrzcińskaRichard H Melloni
Jan 25, 2003·Pharmacology, Biochemistry, and Behavior·Nicole M Avena, Bartley G Hoebel
Mar 18, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Evan N GrafJohn R Mantsch
May 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John R MantschEric S Katz
Aug 24, 2002·The European Journal of Neuroscience·Michela Marinelli, Pier Vincenzo Piazza
Jan 14, 2011·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Min J BaekSangyun Kim
Jun 3, 2014·Brain Research·Glenn F GuerinNicholas E Goeders
Jan 8, 2013·Homeopathy : the Journal of the Faculty of Homeopathy·Iris R BellAudrey J Brooks
Jul 10, 2007·Neuroscience and Biobehavioral Reviews·Nicole M AvenaBartley G Hoebel
Jun 8, 2012·Alcoholism, Clinical and Experimental Research·Blair N CostinMichael F Miles
Aug 14, 2012·The European Journal of Neuroscience·Maria A EsparzaLiliana M Cancela
Aug 16, 2005·Pharmacology, Biochemistry, and Behavior·Nilza Pereira AraujoRoberto Frussa-Filho
Nov 1, 2011·Neuroscience and Biobehavioral Reviews·Thibault RenoirLaurence Lanfumey
Feb 26, 2016·F1000Research·Darius Becker-Krail, Colleen McClung
May 23, 2002·The Journal of Pharmacology and Experimental Therapeutics·Nick E Goeders
Aug 2, 2014·Behavioural Pharmacology·Elena H Chartoff, William A Carlezon
Jul 7, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Constanza Garcia-KellerCarmela M Reichel

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