Stress-induced neuroinflammatory priming is time of day dependent

Psychoneuroendocrinology
Laura K FonkenSteven F Maier

Abstract

Circadian rhythms are endogenous cycles of physiology and behavior that align with the daily rotation of the planet and resulting light-dark cycle. The circadian system ensures homeostatic balance and regulates many aspects of physiology, including the stress response and susceptibility to and/or severity of stress-related sequelae. Both acute and chronic stressors amplify neuroinflammatory responses to a subsequent immune challenge, however it is not known whether circadian timing of the stressor regulates the priming response. Here, we test whether stress-induced neuroinflammatory priming is regulated by the circadian system. As has been previously shown, exposure to 100 inescapable tails shocks (IS) increased hippocampal cytokines following a subsequent inflammatory challenge. However, this effect was limited to animals that experienced the stressor during the light phase. Rats exposed to stress during the dark phase did not alter inflammatory potential following lipopolysaccharide (LPS) challenge. To determine whether microglia might be involved in diurnal differences in neuroinflammatory priming, microglia were isolated 24h after stress that occurred either during the middle of the light or dark phase. Only microglia isola...Continue Reading

References

Aug 1, 1972·The American Journal of Physiology·J DunnP Millet
May 1, 1997·Journal of Neuroimmunology·P TaishiJ M Krueger
Jul 5, 2002·Brain, Behavior, and Immunity·John D JohnsonSteven F Maier
Oct 26, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·John D JohnsonSteven F Maier
Jan 3, 2003·Psychoneuroendocrinology·S Retana-MárquezJ Velázquez-Moctezuma
Jan 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·F HALBERGJ J BITTNER
May 30, 2006·Nature Neuroscience·Astrid E CardonaRichard M Ransohoff
Nov 7, 2006·Current Biology : CB·A J DavidsonG D Block
Oct 24, 2007·Trends in Neurosciences·Knut BiberHendrikus W G M Boddeke
Nov 15, 2007·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Jianhua QiuMichael A Moskowitz
Dec 13, 2007·Nature Reviews. Neuroscience·Robert DantzerKeith W Kelley
Jan 15, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Nancy NaderTomoshige Kino
Nov 18, 2009·Chronobiology International·Luciano MarpeganDiego A Golombek
Jun 24, 2010·Brain, Behavior, and Immunity·Angela M WynneJonathan P Godbout
Oct 15, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oscar Castanon-CervantesAlec J Davidson
Sep 24, 2011·The Journal of Biological Chemistry·John M BusilloJohn A Cidlowski
Nov 2, 2011·Brain, Behavior, and Immunity·Matthew G FrankSteven F Maier
Aug 17, 2012·Proceedings of the National Academy of Sciences of the United States of America·Mary L SpenglerMarina P Antoch
May 29, 2013·Molecular Psychiatry·T A Bedrosian, R J Nelson
Sep 10, 2013·Brain, Behavior, and Immunity·Laura K FonkenRandy J Nelson
May 27, 2014·Frontiers in Cellular Neuroscience·Rosa Chiara PaolicelliMarie-Ève Tremblay
Sep 23, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shlomi CohenHagit Cohen
Nov 30, 2014·Brain, Behavior, and Immunity·Laura K FonkenSteven F Maier
Dec 30, 2014·Brain, Behavior, and Immunity·Derrick J PhillipsIlia N Karatsoreos
Jan 9, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Michael D WeberSteven F Maier
Jan 13, 2015·F1000Research·Ilia N Karatsoreos, Bruce S McEwen
Feb 3, 2015·Brain, Behavior, and Immunity·Kenneth P WrightCharles A Czeisler
Jun 19, 2015·Current Opinion in Endocrinology, Diabetes, and Obesity·Matthew G FrankSteven F Maier

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Citations

May 21, 2016·Frontiers in Endocrinology·Rebecca DumbellHenrik Oster
Sep 3, 2017·Journal of Neuroscience Research·Julia P SegalNader Ghasemlou
Dec 27, 2017·PsyCh Journal·Charlotte Helfrich-Förster
Jan 24, 2019·The New England Journal of Medicine·J A Jeevendra MartynEdward A Bittner
Dec 24, 2019·Stress : the International Journal on the Biology of Stress·Rachel A DautLaura K Fonken
Sep 25, 2019·Cellular and Molecular Neurobiology·Ricardo J Martínez-TapiaLuz Navarro
Aug 23, 2020·Pflügers Archiv : European journal of physiology·Carlos E SantosCarlos C Crestani
Jul 2, 2019·Journal of the Endocrine Society·John D JohnsonDevanshi M Mehta
Nov 13, 2018·Frontiers in Behavioral Neuroscience·Julie E Finnell, Susan K Wood
Jun 6, 2019·Frontiers in Physiology·Juan Hernández-PérezMarcos A López-Patiño
Dec 18, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessie MuirRosemary C Bagot
Feb 13, 2020·Frontiers in Psychiatry·Agorastos AgorastosPanagiota Pervanidou
Dec 3, 2020·Anesthesia and Analgesia·Yinhui ZhouJ A Jeevendra Martyn
Jan 12, 2020·Immunity·Charlotte MadoreOleg Butovsky
Jan 8, 2021·European Journal of Psychotraumatology·Agorastos Agorastos, Miranda Olff
Mar 11, 2018·Brain, Behavior, and Immunity·Laura K FonkenSteven F Maier
Nov 7, 2017·Brain, Behavior, and Immunity·Matthew G FrankSteven F Maier
Mar 17, 2021·The European Journal of Neuroscience·Jeniffer Sanguino-GómezHarm J Krugers
Aug 8, 2021·International Journal of Molecular Sciences·Mohammed E ChoudhuryJunya Tanaka

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