Stress-induced protein aggregates shape population heterogeneity in bacteria

Current Genetics
Julien MortierAbram Aertsen

Abstract

The concept of phenotypic heterogeneity preparing a subpopulation of isogenic cells to better cope with anticipated stresses has been well established. However, less is known about how stress itself can drive subsequent cellular individualization in clonal populations. In this perspective, we focus on the impact of stress-induced cellular protein aggregates, and how their segregation and disaggregation can act as a deterministic incentive for heterogeneity in the population emerging from a stressed ancestor.

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Citations

Sep 29, 2019·Current Genetics·Ewa Laskowska, Dorota Kuczyńska-Wiśnik
Sep 26, 2019·Scientific Reports·Nojood A AalismailCarlos M Duarte
Mar 3, 2020·Frontiers in Microbiology·Hui LiMichael G Gänzle
May 8, 2021·Comprehensive Reviews in Food Science and Food Safety·Erdogan CeylanHeidy M W den Besten
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Ulrich Karl Steiner

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