Stress-induced sensitization of the limbic system in ovariectomized rats is partly restored by cyclic 17beta-estradiol administration

The European Journal of Neuroscience
Marjolein GerritsG J Ter Horst

Abstract

Chronic stress induces neurobiological alterations which have consequences for subsequent stress handling. In the current experiment, ovariectomized rats were subjected daily to a stressor for 21 days. Thereafter, the rats were treated for 21 days with 17beta-estradiol benzoate (10 microg/250 g, once every 4 days) or mirtazapine (10 mg/kg, daily). In this way, we were able to evaluate the ability of these compounds to reverse chronic stress-induced changes in the activity of the limbic system. After 21 days of recovery and treatment, the rats were re-exposed to the adverse environment of the initial stressor and perfused 2 h later. Ovariectomized rats displayed increased numbers of c-Fos-positive nuclei, after re-exposure to the stressor, in the paraventricular nucleus of the hypothalamus, dentate gyrus, medial prefrontal cortex and central and medial amygdala. Cyclic estradiol treatment attenuated the sensitization of the paraventricular nucleus and central amygdala. Mirtazapine increased the number of c-Fos-positive nuclei in the central amygdala and dentate gyrus. Long-term transcriptional changes induced by chronic stress were determined with DeltaFosB immunoreactivity. The medial prefrontal cortex showed an increased numbe...Continue Reading

References

Jan 1, 1992·Canadian Journal of Physiology and Pharmacology·R A Swanson
Mar 1, 1991·Brain Research. Molecular Brain Research·E Mohr, E Schmitz
Aug 11, 1995·Science·M M Weissman, M Olfson
Jun 1, 1995·The American Journal of Psychiatry·K S KendlerL J Eaves
Jul 1, 1993·Physiology & Behavior·R E Adamec, T Shallow
Apr 1, 1996·Physiology & Behavior·P MeerloR H Van den Hoofdakker
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·I M RachmanR S Cohen
Dec 5, 1998·Neurochemistry International·K J Kovács
Apr 15, 1999·Annual Review of Neuroscience·B S McEwen
Jun 16, 1999·Journal of Abnormal Psychology·L J MetzgerR K Pitman
Jul 2, 1999·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·S Carranza-Lira, M L Valentino-Figueroa
Aug 24, 1999·The Journal of Clinical Psychiatry·P J GoodnickB V Freund
Aug 5, 2000·JAMA : the Journal of the American Medical Association·C HeimC B Nemeroff
Aug 15, 2000·Psychological Review·S E TaylorJ A Updegraff
Nov 15, 2000·The Journal of Clinical Psychiatry·A J Gelenberg, C L Chesen
Jul 31, 2001·Molecular and Cellular Endocrinology·M A LovenA M Nardulli
Oct 13, 2001·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·L DazziG Biggio
Oct 17, 2001·CNS Drugs·U Halbreich, L S Kahn
Jan 16, 2002·Physiology & Behavior·F K MarcondesR C Spadari-Bratfisch
Jul 19, 2002·JAMA : the Journal of the American Medical Association·Jacques E RossouwUNKNOWN Writing Group for the Women's Health Initiative Investigators
Oct 9, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Nassia Kioukia-FougiaZeta Papadopoulou-Daifoti
Jan 28, 2003·Biological Psychiatry·Jonathan R T DavidsonSusan van Meter
Mar 21, 2003·Journal of Affective Disorders·Ronald C Kessler

❮ Previous
Next ❯

Citations

Sep 12, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·William ReillyLeslie L Devaud
Jan 31, 2012·The Journal of Pharmacology and Experimental Therapeutics·Havan FurmagaAlan Frazer
Dec 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lisa Y MaengTracey J Shors
May 18, 2016·Pharmacology, Biochemistry, and Behavior·Nikolaos KokrasChristina Dalla
Aug 30, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·S DeurveilherK Semba
Dec 19, 2009·Neuropharmacology·Herbert E CovingtonEric J Nestler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.