Stress-induced transposon reactivation: a mediator or an estimator of allostatic load?

Environmental Epigenetics
Daniel Nätt, Annika Thorsell

Abstract

Transposons are playing an important role in the evolution of eukaryotic genomes. These endogenous virus-like elements often amplify within their host genomes in a species specific manner. Today we have limited understanding when and how these amplification events happens. What we do know is that cells have evolved multiple line of defenses to keep these potentially invasive elements under control, often involving epigenetic mechanisms such as DNA-methylation and histone modifications. Emerging evidence shows a strong link between transposon activity and human aging and diseases, as well as a role for transposons in normal brain development. Controlling transposon activity may therefore uphold the fine balance between health and disease. In this article we investigate this balance, and sets it in relation to allostatic load, which conceptualize the link between stress and the "wear and tear" of the organism that leads to aging and disease. We hypothesize that stress-induced retrotransposon reactivation in humans may be used to estimate allostatic load, and may be a possible mechanism in which transposons amplify within species genomes.

References

Jun 1, 1975·Journal of Human Stress·H Selye
Dec 1, 1992·Current Opinion in Genetics & Development·D J Finnegan
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KimA Bucheton
Jul 1, 1997·Experimental Gerontology·B Villeponteau
Jun 18, 2002·Current Opinion in Cell Biology·Alan M Weiner
Dec 6, 2002·Nature·UNKNOWN Mouse Genome Sequencing ConsortiumEric S Lander
Jul 22, 2005·Journal of Evolutionary Biology·R Bijlsma, V Loeschcke
Nov 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Erin HaithcockJun Liu
Apr 29, 2006·Science·Paola Scaffidi, Tom Misteli
May 27, 2006·Proceedings of the National Academy of Sciences of the United States of America·Hal P BogerdBryan R Cullen
Jun 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Dale K ShumakerRobert D Goldman
Jun 6, 2006·Nature·Angélique GirardMichelle A Carmell
Jun 6, 2006·Nature·Alexei AravinThomas Tuschl
Jun 13, 2006·Genes & Development·Shane T GrivnaHaifan Lin
Apr 21, 2007·Science·Alexei A AravinGregory J Hannon
Jun 15, 2007·Trends in Genetics : TIG·Mario F Fraga, Manel Esteller
Nov 14, 2007·PLoS Computational Biology·Doron BetelChris Sander
Jan 19, 2008·Genetics·Michael A CantrellHolly A Wichman
Mar 28, 2008·Nature Reviews. Genetics·Cédric Feschotte
Aug 30, 2008·Cell·Daniel B StetsonRuslan Medzhitov
Oct 16, 2008·Cell·John L Goodier, Haig H Kazazian
Jan 20, 2009·Mechanisms of Ageing and Development·Valentina BollatiAndrea Baccarelli
May 15, 2009·Genome Research·Jinchuan XingLynn B Jorde
Aug 7, 2009·Nature·Nicole G CoufalFred H Gage
Sep 19, 2009·Nature Reviews. Genetics·Richard Cordaux, Mark A Batzer
Sep 23, 2009·Hippocampus·Alysson R MuotriFred H Gage
Oct 14, 2009·Neuroscience and Biobehavioral Reviews·Robert-Paul JusterSonia J Lupien
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Richard G HunterBruce S McEwen
Jan 16, 2010·Nature·Helen M RoweDidier Trono
Jul 7, 2010·Cell·Cheng Ran Lisa HuangKathleen H Burns
Oct 29, 2010·Genome Research·Adam D Ewing, Haig H Kazazian
Nov 26, 2010·Animal Genetics·S CapomaccioK Cappelli
Feb 8, 2011·Brain, Behavior, and Immunity·V BollatiA Baccarelli
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ian MazeEric J Nestler
Feb 22, 2011·Age·Dina BellizziGiuseppe Passarino
Nov 1, 2011·Nature·J Kenneth BaillieGeoffrey J Faulkner
Nov 30, 2011·Nature Reviews. Genetics·Todd J Treangen, Steven L Salzberg
Dec 14, 2011·Development, Growth & Differentiation·Hidetaka Ito

❮ Previous
Next ❯

Citations

Jul 13, 2018·Stress : the International Journal on the Biology of Stress·Ugo CappucciLucia Piacentini
May 16, 2018·Clinical Epigenetics·Eric S CokerBrenda Eskenazi
May 28, 2019·Stress : the International Journal on the Biology of Stress·Haruka Wada
Jul 26, 2016·Environmental Epigenetics·Rodriguez-Martinez Heriberto
Feb 27, 2020·Cell Reports·Swapnil S ParhadWilliam E Theurkauf
Feb 23, 2021·Biological Reviews of the Cambridge Philosophical Society·Roberta BergeroSimone Immler
Mar 13, 2021·Journal of Child & Adolescent Trauma·Ellen Wikenius

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Genetics & Epigenetics of Aging

Dozens of genes are implicated in lifespan, and epigenetic changes during aging affect cell function. This feed focuses on the genetics and epigenetics of aging.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.