PMID: 9430796Feb 7, 1998Paper

Stress-induced visceral hypersensitivity to rectal distension in rats: role of CRF and mast cells

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
M GuéL Buéno

Abstract

Psychological factors have long been implicated in the aetiology of irritable bowel syndrome often associated with abdominal pain. This work was designed to study, in rats, the influence of partial restraint stress on the abdominal cramps induced by rectal distension and to determine the role of corticotropin releasing factor (CRF) and mast cells degranulation in this response. Abdominal contractions were electromyographically recorded. Thirty minutes after stress or intracerebroventricular CRF, rectal distension was performed by inflation of a balloon (0.4-1.2 mL). alpha-helical CRF9-41 or doxantrazole were administered centrally (15 min) and intraperitoneally (30 min), respectively, before stress. Histamine release and the number of mast cells were determined in colonic pieces from stressed and control rats. Stress and CRF enhanced the number of abdominal cramps evoked by rectal distension without affecting rectal compliance. alpha-helical CRF9-41 and doxantrazole antagonized the stress and CRF-induced enhancement of abdominal cramps. Stress increased the colonic histamine content whereas the number of colonic mast cells was unchanged. Stress enhances abdominal contractions in response to rectal distension in rats via pathway...Continue Reading

Citations

Feb 24, 2001·Journal of Physiology and Biochemistry·O Martínez-AugustínF Sánchez de Medina
Oct 5, 2010·Psychopharmacology·Siobhain M O'MahonyJohn F Cryan
Dec 19, 2003·Current Allergy and Asthma Reports·Ali A Siddiqui, Philip B Miner
May 4, 2011·Current Gastroenterology Reports·Giovanni BarbaraRoberto Corinaldesi
Sep 12, 2000·Current Gastroenterology Reports·H R Mertz
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Hiroshi AkiyamaJohn Bienenstock
Jun 28, 2000·Physiology & Behavior·W D GunterB Greenwood-Van Meerveld
Feb 24, 2001·The Surgical Clinics of North America·Y Ringel, D A Drossman
Apr 2, 2003·Pharmacology, Biochemistry, and Behavior·Beverley Greenwood-Van MeerveldDebra Sutkowski-Markmann
Dec 17, 2002·Current Opinion in Pharmacology·Gareth J Sanger, Gareth A Hicks
Feb 1, 2003·Autonomic Neuroscience : Basic & Clinical·Beverley Greenwood-Van MeerveldBengt Linderoth
Oct 3, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Richard KirschRobert Riddell
Feb 29, 2000·British Journal of Pharmacology·M ToulouseL Buéno
Aug 17, 2002·Alimentary Pharmacology & Therapeutics·M CamilleriW G Thompson
Aug 30, 2008·Journal of Gastroenterology and Hepatology·Yong S KimSuck C Choi
Sep 29, 1998·The Journal of Pharmacy and Pharmacology·C LachezeL Buéno
Aug 24, 1999·Gut·J D WoodP L Andrews
May 2, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Muriel LaraucheYvette Taché
Nov 21, 2009·American Journal of Physiology. Gastrointestinal and Liver Physiology·Feli SmithAdam J Moeser
Nov 8, 2003·American Journal of Respiratory and Critical Care Medicine·Paul ForsytheHarissios Vliagoftis
Oct 1, 2010·Experimental Biology and Medicine·Andreas Stengel, Yvette Taché
Apr 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yu Fu, Volker Neugebauer
Jan 22, 2008·World Journal of Gastroenterology : WJG·Jun-Ho LaIl-Suk Yang
Aug 24, 2011·Journal of Neurogastroenterology and Motility·Muriel LaraucheYvette Taché
Jul 28, 2012·Journal of Neurogastroenterology and Motility·Robin Spiller, Ching Lam
Sep 30, 2000·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M O'SullivanC A O'Morain
Mar 5, 2002·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S BradesiL Buéno
Mar 15, 2014·World Journal of Gastroenterology : WJG·Agata MulakMuriel Larauche
Dec 24, 2005·Scandinavian Journal of Gastroenterology·Helene LettesjöMagnus Simrén
Apr 26, 2006·Expert Opinion on Emerging Drugs·Sylvie BradesiEmeran Mayer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Sylvie BradesiL Buéno
American Journal of Physiology. Gastrointestinal and Liver Physiology
Muriel LaraucheJames A McRoberts
Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
T LemboEmeran A Mayer
© 2021 Meta ULC. All rights reserved