Stress-induced visceral pain: toward animal models of irritable-bowel syndrome and associated comorbidities

Frontiers in Psychiatry
Rachel D MoloneyJohn F Cryan

Abstract

Visceral pain is a global term used to describe pain originating from the internal organs, which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders such as irritable-bowel syndrome (IBS). Currently, the treatment strategies targeting visceral pain are unsatisfactory, with development of novel therapeutics hindered by a lack of detailed knowledge of the underlying mechanisms. Stress has long been implicated in the pathophysiology of visceral pain in both preclinical and clinical studies. Here, we discuss the complex etiology of visceral pain reviewing our current understanding in the context of the role of stress, gender, gut microbiota alterations, and immune functioning. Furthermore, we review the role of glutamate, GABA, and epigenetic mechanisms as possible therapeutic strategies for the treatment of visceral pain for which there is an unmet medical need. Moreover, we discuss the most widely described rodent models used to model visceral pain in the preclinical setting. The theory behind, and application of, animal models is key for both the understanding of underlying mechanisms and design of future therapeutic interventions. Taken together, it is apparent that stress-induced visceral p...Continue Reading

References

Mar 1, 1979·Brain : a Journal of Neurology·A RustioniS O'Neill
Jan 1, 1992·Neuroscience and Biobehavioral Reviews·R Muscat, P Willner
Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·J GriffithsH Anisman
Dec 1, 1990·Annals of Internal Medicine·D A DrossmanC M Mitchell
Jun 1, 1990·Gastroenterology·W E WhiteheadM M Schuster
Feb 1, 1989·Endocrine Reviews·A BatemanS Solomon
Apr 1, 1988·Acta Anaesthesiologica Scandinavica·S ArnérL L Gustafsson
Nov 1, 1963·The American Journal of Physiology·V CritchlowH S Lipscomb
Oct 1, 1980·Journal of Endocrinological Investigation·C F Allen-RowlandsM Wilson
Aug 1, 1983·Postgraduate Medicine·R J Stoney, L M Reilly
Sep 27, 1993·Archives of Internal Medicine·B S McEwen, E Stellar
Dec 1, 1996·Gastroenterology·S M CollinsH P Weingarten
Nov 1, 1996·Digestive Diseases and Sciences·W E WhiteheadE Taub
Dec 1, 1996·The Journal of Clinical Psychiatry·C IrwinW Brener
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Feb 7, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M GuéL Buéno
Mar 13, 1998·Gastroenterology·Q Aziz, D G Thompson
Jun 3, 1998·The Journal of Neuropsychiatry and Clinical Neurosciences·H Selye
Dec 4, 1998·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·B K TsangJ H Eichhorn
Jan 6, 1999·Biochemical and Biophysical Research Communications·S IsomotoK Taniyama
Mar 11, 1999·Current Opinion in Neurobiology·D D Francis, M J Meaney
Apr 15, 1999·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·Y TachéJ Rivier

❮ Previous
Next ❯

Citations

Feb 18, 2016·Molecular and Cellular Pediatrics·Bruno P Chumpitazi, Robert J Shulman
Feb 26, 2016·Autonomic Neuroscience : Basic & Clinical·Thelma A Lovick
Aug 16, 2016·Current Opinion in Behavioral Sciences·Nicole C Victoria, Anne Z Murphy
Dec 27, 2015·Birth Defects Research. Part C, Embryo Today : Reviews·Siobhain M O' MahonyJohn F Cryan
Dec 15, 2015·CNS Neuroscience & Therapeutics·Rachel D MoloneyJohn F Cryan
Mar 15, 2016·Frontiers in Pharmacology·Gabriella Aviello, Giuseppe D'Agostino
Dec 10, 2015·Journal of Neurogastroenterology and Motility·Shan LiMeiyun Ke
Apr 2, 2016·Journal of Neurogastroenterology and Motility·Jaehoon Jahng, Yong Sung Kim
Oct 27, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J ScanziM Dapoigny
Jul 30, 2016·Gut Microbes·Hans RaskovJacob Rosenberg
Jan 11, 2016·Journal of Neuroendocrinology·B Greenwood-Van MeerveldM Vicario
Aug 22, 2016·Biochimica Et Biophysica Acta. General Subjects·Ibtissem GhouzaliMoïse Coëffier
Jul 10, 2016·Neuropharmacology·P J KennedyG Clarke
Dec 7, 2016·Nature Reviews. Urology·Carsten LeueGommert van Koeveringe
Jan 18, 2017·Reproductive Sciences·Siomara HernandezCaroline B Appleyard
Feb 18, 2017·Gastroenterology Research and Practice·Hanna Edebol-CarlmanRobert J Brummer
Jan 6, 2018·Journal of Clinical Medicine·Maria Giuliana Vannucchi, Stefano Evangelista
Mar 24, 2018·Future Science OA·Kathleen F Holton, Elizabeth W Cotter
Nov 11, 2018·The Journal of Pharmacology and Experimental Therapeutics·John P RussellBeverley Greenwood-Van Meerveld
Aug 15, 2018·International Journal of Molecular Medicine·Shengtao ZhuShutian Zhang
Aug 4, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·John W WileyShuangsong Hong
May 26, 2016·MMW Fortschritte der Medizin·Peter C Konturek, Yurdagül Zopf
Sep 10, 2017·Wiener medizinische Wochenschrift·Gabriele MoserJohannes Peter
Sep 25, 2019·Animals : an Open Access Journal From MDPI·Rebecca P GeorgeAlexandra L Whittaker
Mar 1, 2017·Gastroenterology Research and Practice·Fang ZhangHuirong Liu
Aug 19, 2020·Scientific Reports·Selvaraj SubramaniyamSanjib Bhattacharyya
Jun 9, 2018·International Journal of Molecular Sciences·Valentina Caputi, Maria Cecilia Giron
Jan 11, 2019·BioMed Research International·Zhuo-Ying TaoDong-Yuan Cao
Feb 21, 2019·Experimental and Therapeutic Medicine·Yanxia GongYang Xu
Jun 14, 2019·Frontiers in Cellular and Infection Microbiology·Si LiuShengtao Zhu

❮ Previous
Next ❯

Methods Mentioned

BETA
in silico techniques
hormone replacement therapy
transgenic
histone acetylation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved