Stress-like adrenocorticotropin responses to caffeine in young healthy men

Pharmacology, Biochemistry, and Behavior
William R LovalloMichael F Wilson

Abstract

The effects of oral caffeine (3.3 mg/kg, equivalent to 2-3 cups of coffee) on plasma adrenocorticotropin (ACTH) and cortisol (CORT) were tested in 47 healthy young men at rest in a double-blind, placebo-controlled, crossover study. Following caffeine, ACTH was significantly elevated at all times from 30 min to 180 min, and CORT was elevated from 60 min to 120 min (Fs > or = 8.4, ps < 0.01). Peak increases relative to placebo were: ACTH, 33% (+5.2 pg/ml) and CORT, 30% (+2.7 micrograms/dl) at 60 min postcaffeine. The results suggest that caffeine can activate important components of the pituitary-adrenocortical response in humans during the resting state. Caffeine's known ability to increase CORT production appears at least partly due to an increase in ACTH release at the pituitary.

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Citations

Aug 8, 2009·Psychopharmacology·Emily R HawkenNicholas J Delva
Apr 5, 2011·European Journal of Applied Physiology·Bart RoelandsRomain Meeusen
Dec 4, 2003·Psychoneuroendocrinology·G H IceR L Kane
May 3, 2006·Journal of Personality and Social Psychology·Sally I PowersAline Sayer
Jul 20, 2002·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Ron BouchardJonathan D Geiger
Oct 6, 2005·Psychosomatic Medicine·William R LovalloMichael F Wilson
Nov 28, 2001·The Journal of Clinical Hypertension·T R HartleyM F Wilson
Apr 1, 2014·Psychopharmacology·Jan Alexander HäusserAndreas Mojzisch
May 27, 2010·Journal of Women's Health·Noha H FaragWilliam R Lovallo
Nov 14, 2007·Metabolism: Clinical and Experimental·Todd MacKenzieJohn A Baron
Mar 14, 2007·Psychoneuroendocrinology·Anette HarrisHege R Eriksen
Apr 25, 2006·Pharmacology, Biochemistry, and Behavior·William R LovalloMichael F Wilson
Oct 3, 2015·Journal of the American Podiatric Medical Association·Mohomad Al SawahFortunato Battaglia
Jul 24, 2012·Pharmacology, Biochemistry, and Behavior·Grace E GilesRobin B Kanarek
Jan 4, 2017·Canadian Journal of Physiology and Pharmacology·Grace E GilesRobin B Kanarek
Nov 23, 2018·Medicina·Michał K ZarobkiewiczBarbara Jodłowska-Jędrych
Jan 11, 2007·Journal of Physiological Anthropology·Tomoko Ueno, Tadakatsu Ohnaka
Aug 5, 2017·Geriatrics & Gerontology International·Aline Talita Dos SantosJuliana Nery de Souza-Talarico
Oct 4, 2019·Stress : the International Journal on the Biology of Stress·Melissa WallsUNKNOWN Gathering for Health Team
May 29, 2000·American Journal of Hypertension·J D ShepardW R Lovallo

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