Stress proteins may provide a link between the immune response to infection and autoimmunity

International Immunology
J R LambD B Young

Abstract

Stress proteins are frequently the target of humoral and cell-mediated immune responses to infection. These proteins belong to highly conserved gene families and there is substantial sequence homology between antigens produced by pathogenic organisms and the corresponding proteins from mammalian cells. Human T cells from sites of infectious and autoimmune lesions proliferate in response to stress proteins, and mapping of antigenic determinants on a mycobacterial stress protein shows that both species specific and highly conserved, 'self-like', regions of the molecule can take part in immune recognition. It is proposed that the lymphocyte population induced in response to stress proteins of pathogens during infection includes cells capable of autoimmune recognition of the corresponding self protein. Local accumulation of self stress proteins--in response to viral infection, for example--may subsequently provide a stimulus for proliferation of such autoreactive lymphocytes, thereby triggering a cycle of events which may contribute to the pathological damage associated with autoimmune disease.

Citations

Oct 1, 1990·Antonie van Leeuwenhoek·D B Young
Jan 1, 1991·Springer Seminars in Immunopathology·S H Kaufmann
Nov 30, 1994·Experientia·B Maresca, G S Kobayashi
Jul 15, 1992·Experientia·S H Kaufmann
Jan 1, 1992·International Journal of Clinical & Laboratory Research·J S Gaston
Jan 1, 1992·International Journal of Clinical & Laboratory Research·S H Kaufmann
Jun 2, 2012·Indian Journal of Microbiology·Gautam Kaul, Hitesh Thippeswamy
Feb 12, 2009·Cell Stress & Chaperones·Attila MolvarecJános Rigó
Dec 15, 1990·Biochemical Pharmacology·Y R DonatiB S Polla
Dec 16, 1991·Clinica Chimica Acta; International Journal of Clinical Chemistry·B Pérez-MacedaC Bernabeu
Oct 6, 1989·Cell·R A Young, T J Elliott
Jan 1, 1993·Molecular Aspects of Medicine·R H Burdon
Apr 1, 1990·Immunology Today·S H Kaufmann
May 1, 1991·Vaccine·P Fine, H Dockrell
Sep 1, 1990·Research in Immunology·A J GatrillS H Kaufmann
Sep 1, 1990·Research in Immunology·R L BolhuisE Braakman
Feb 1, 1989·Current Opinion in Immunology·S H Kaufmann
Apr 1, 1995·The Journal of Steroid Biochemistry and Molecular Biology·M BrönnegårdJ A Gustafsson
Mar 1, 1994·Trends in Microbiology·S Jindal, M Malkovsky
Aug 2, 2003·Cancer Detection and Prevention·Li ZhongEdward A Hirschowitz
Mar 24, 2004·Brain Research Bulletin·Gülgün TezelMartin B Wax
Jun 24, 2000·FEMS Immunology and Medical Microbiology·H MaedaY Murayama
Jun 1, 1992·Baillière's Clinical Rheumatology·J S Gaston
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M Clerget, B S Polla
Jan 4, 1994·Proceedings of the National Academy of Sciences of the United States of America·M TsujiS Tonegawa
Oct 1, 1993·The Journal of Experimental Medicine·H Udono, P K Srivastava
Mar 1, 1995·The Journal of Experimental Medicine·S M AndertonW van Eden
Aug 1, 1995·Tissue Antigens·S Ramachandran, R B Bell
Jul 1, 1997·Tissue Antigens·J VinascoJ Martín
May 1, 1995·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·P G Holt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.