PMID: 8986011Dec 1, 1996Paper

Stress reinstates cocaine-seeking behavior after prolonged extinction and a drug-free period

Psychopharmacology
S ErbJ Stewart

Abstract

We have shown previously, using an animal model of relapse, that acute exposure to intermittent footshock stress induces reinstatement of heroin-taking behavior in rats. Here we report that in rats trained to self-administer cocaine, exposure to acute intermittent footshock stress induces reinstatement of cocaine-taking behavior after prolonged extinction sessions and after a 4- to 6-week drug-free period; an effect comparable to that induced by a priming injection of cocaine. Animals were initially allowed to self-administer cocaine HCl (1.0 mg/kg per infusion, i.v.) during one 3-h session/day for 12 days. Subsequently, extinction conditions were introduced by substituting saline for cocaine so that lever-pressing resulted in i.v. infusions of saline rather than of drug. Extinction conditions were maintained until animals made 15 responses or less in the 3 h, after which animals were given saline infusions at the start of each daily session to establish baseline responding of ten responses or less. Subsequently, animals were tested for reinstatement of responding for saline infusions following a non-contingent injection of cocaine (2.0 mg/kg, i.v.) and exposure to intermittent footshock (10 min, 0.5 mA, 0.5 s on, mean off peri...Continue Reading

Citations

Jun 9, 2004·Neurotoxicity Research·Bita Moghaddam, Mark Jackson
Jun 15, 2007·Psychopharmacology·Ayelet CooperAbraham Zangen
Jun 26, 2008·Psychopharmacology·Van A Redila, Charles Chavkin
Oct 3, 2009·Psychopharmacology·Bruno Ribeiro Do CoutoJose Miñarro
Mar 15, 2011·Psychopharmacology·Michelle L JobesKenzie L Preston
May 19, 2011·Psychopharmacology·Lucia CaffinoFabio Fumagalli
Jan 18, 2012·Psychopharmacology·Amanda T CampbellFrancesco Leri
Jan 18, 2007·Behavior Genetics·Morgane Thomsen, S Barak Caine
Oct 26, 2006·Behavior Genetics·Colin N HaileTherese A Kosten
Jun 18, 2005·Brain Research. Brain Research Reviews·Christian A HeidbrederCharles R Ashby
Aug 7, 2013·Neuropharmacology·John R MantschJordan M Blacktop
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Eliot L Gardner
Dec 31, 2002·Chemistry and Physics of Lipids·Eliot L Gardner
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Ronald E See
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Apr 29, 1998·Trends in Pharmacological Sciences·P V Piazza, M Le Moal
Dec 26, 2001·Psychoneuroendocrinology·Nick E Goeders

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