Stress-related hormones affect carbohydrate metabolism in Drosophila females

Archives of Insect Biochemistry and Physiology
E K KarpovaN E Gruntenko

Abstract

A highly conservative insulin signaling pathway, stable work of which is indicated by carbohydrates metabolism, is also known to play an important role in the control of stress resistance. Here we demonstrate that exposure to heat stress leads to a rise in the levels of trehalose and glucose in females of Drosophila melanogaster, but does not affect the expression level of the trehalase (Treh) gene. We have shown that the rise in juvenile hormone (JH) and dopamine decreases levels of both carbohydrates under the normal conditions but brings them to values close to normal following the stress exposure. The data obtained suggest that (a) dopamine and JH involved in the neuroendocrine stress reaction in D. melanogaster also take part in the regulation of carbohydrates metabolism, tending to normalize it after stress; (b) the regulation of trehalose content under stress does not occur at the level of transcription of the degrading enzyme.

References

May 15, 1996·Experientia·A BeckerG Wegener
Mar 11, 2003·Glycobiology·Alan D ElbeinDavid Carroll
Feb 15, 2005·Proceedings of the National Academy of Sciences of the United States of America·Susan J BroughtonLinda Partridge
Jun 3, 2006·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·I Iu RauschenbachE K Karpova
Oct 30, 2009·International Journal of Molecular Sciences·Gabriel IturriagaBarbara Nova-Franco
Jul 2, 2011·Disease Models & Mechanisms·Laura Palanker MusselmanThomas J Baranski
Apr 18, 2013·Brain Research Bulletin·Nadezhda Bazhan, Dóra Zelena
May 31, 2017·General and Comparative Endocrinology·N E Gruntenko, I Yu Rauschenbach

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Citations

May 12, 2020·Frontiers in Physiology·Jan LubawyPaweł Marciniak
Dec 18, 2020·Frontiers in Physiology·Sanjay TevatiyaRajnikant Dixit

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