Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat) in the body than development at 25°C. Gene expression analysis between the flies developed at 18°C and 25°C revealed that the Immune deficiency (Imd) pathway, including the downstream antimicrobial peptides (AMPs), is downregulated in the flies developed at 18°C. When hypomorphic imd mutant flies with reduced AMP expressions were developed at 25°C, they showed induced stress resistance with higher fat content in the body similar to the wild-type flies developed at 18°C. However, severe hypomorphic imd mutants could not enhance stress resistance due to the downregulation of another downstream JNK pathway that expresses stress tolerance genes. Interestingly, the downregulation of AMP genes, itself, extended lifespan with increased stress resistance. Especially, fat body-specific downregulation of Imd AMP genes exhibited a longer lifespan with higher heat resistance. The fat body is known to function in metabolic homeostasis, stress tolerance, growth, and longevity in Drosophila. Here, we provi...Continue Reading
daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans
A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function
Drosophila immune deficiency (IMD) is a death domain protein that activates antibacterial defense and can promote apoptosis
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
JNK signaling in insulin-producing cells is required for adaptive responses to stress in Drosophila.
The immune response attenuates growth and nutrient storage in Drosophila by reducing insulin signaling.
Enhancement of stress resistances and downregulation of Imd pathway by lower developmental temperature in Drosophila melanogaster
Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA
Dysregulation of antimicrobial peptide expression distinguishes Alzheimer's disease from normal aging
Age, sex, adult and larval diet shape starvation resistance in the Mediterranean fruit fly: an ecological and gerontological perspective
Aging Genetics (Keystone)
This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.