Stress response inhibits the nephrotoxicity of cisplatin

American Journal of Physiology. Renal Physiology
Marie H HaniganMaia G Lapus

Abstract

Salt loading and saline hydration are used to protect patients from cisplatin-induced nephrotoxicity. The mechanism by which salt exerts its protective effect is unknown. As part of an ongoing study of cisplatin nephrotoxicity, an in vitro assay system was developed that models the in vivo exposure and response of proximal tubule cells to cisplatin. In this study, it was discovered that the toxicity of cisplatin toward LLC-PK(1) cells varied dramatically according to the tissue culture media used for 3-h cisplatin exposure. Further experiments revealed that minor variations in the sodium concentration among standard tissue culture media modulated cisplatin nephrotoxicity. NaCl has been shown to protect against cisplatin-induced nephrotoxicity in vivo but has never before been demonstrated in vitro. NaCl did not alter the cellular accumulation of cisplatin. NaCl altered the osmolarity of the external media, and its effect was replicated by substituting equiosmolar concentrations of impermeant anions or cations. The change in osmolarity triggered a stress response within the cell that modulated sensitivity to cisplatin. These data resolve several long-standing controversies regarding the mechanism by which salt loading protects t...Continue Reading

References

May 1, 1992·The American Journal of Physiology·D Filipovic, H Sackin
Jun 1, 1990·Antimicrobial Agents and Chemotherapy·R Sabra, R A Branch
Oct 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D BajorinR Fein
Jul 1, 1985·Biochemical Pharmacology·P T Daley-Yates, D C McBrien
Jan 1, 1984·Annals of Internal Medicine·R F OzolsR C Young
Jan 1, 1994·Cancer Chemotherapy and Pharmacology·V PinzaniP Balmès
Aug 1, 1993·Gynecologic Oncology·T L Cornelison, E Reed
May 1, 1997·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·P R WachsbergerR A Coss
Apr 20, 2000·The Journal of Clinical Investigation·J Y ChoiM Baum
Jul 28, 2001·Kidney International·Y TeradaF Marumo
Nov 7, 2001·The American Journal of Pathology·M H HaniganM W Lieberman
Dec 6, 2001·The Journal of Biological Chemistry·Jaekwon LeeDennis J Thiele
Dec 26, 2001·The Journal of Pharmacology and Experimental Therapeutics·Danyelle M Townsend, Marie H Hanigan
Mar 21, 2002·Proceedings of the National Academy of Sciences of the United States of America·Lawrence H Einhorn
Oct 9, 2002·Proceedings of the National Academy of Sciences of the United States of America·Seiko IshidaIra Herskowitz
Oct 23, 2002·Molecular Pharmacology·Xinjian LinStephen B Howell
Nov 28, 2002·American Journal of Physiology. Renal Physiology·Karen L WuJeffrey R Schelling
Dec 31, 2002·Journal of the American Society of Nephrology : JASN·Danyelle M TownsendMarie H Hanigan

❮ Previous
Next ❯

Citations

Apr 21, 2005·Kidney International·Premalatha BalachandranDavid S Pasco
Sep 21, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Bidya Dhar SahuRamakrishna Sistla
Mar 15, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Badreldin H Ali, Mansour S Al Moundhri
Jan 22, 2015·Electrolyte & Blood Pressure : E & BP·Gi-Su OhHong-Seob So
Feb 6, 2018·Journal of Otolaryngology - Head & Neck Surgery = Le Journal D'oto-rhino-laryngologie Et De Chirurgie Cervico-faciale·Takahiro KimuraYasuhisa Hasegawa
May 23, 2019·Journal of Biochemical and Molecular Toxicology·Bahareh HakiminiaAzadeh Moghaddas
Mar 3, 2012·Archives of Toxicology·Neife Aparecida Guinaim dos SantosAntonio Cardozo dos Santos
Apr 24, 2014·Indian Journal of Clinical Biochemistry : IJCB·Seyed Kazem Bagherpour DounAzim Akbarzadeh
Sep 26, 2014·American Journal of Physiology. Cell Physiology·Belinda Halling SørensenIan Henry Lambert
Apr 23, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Md Abdul Hye KhanJohn D Imig
Nov 20, 2019·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Laksmi Kusuma WardhaniAchmad Chusnu Romdhoni
Aug 19, 2007·The American Journal of the Medical Sciences·Xin YaoKenneth Nugent
Jan 20, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T A AjithN P Sudheesh

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.