Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes

Cell and Tissue Research
Keith E Latham

Abstract

Oocytes and early stage embryos are highly sensitive to variation in diverse exogenous factors such as temperature, osmolarity, oxygen, nutrient restriction, pH, shear stress, toxins, amino acid availability, and lipids. It is becoming increasingly apparent that many such factors negatively affect the endoplasmic reticulum, protein synthesis and protein processing, initiating ER stress and unfolded protein responses. As a result, ER stress signaling serves as a common mediator of cellular responses to diverse stressors. In oocytes and embryos, this leads to developmental arrest and epigenetic changes. Recent studies have revealed that preventing ER stress or inhibiting ER stress signaling can preserve or even enhance oocyte and embryo developmental potential. This review examines ER stress signaling, how it arises, how it affects oocytes and embryos, and how its occurrence can be managed or prevented.

References

Jan 1, 1992·Molecular Reproduction and Development·Y UmaokaT Mori
Oct 1, 1991·Journal of in Vitro Fertilization and Embryo Transfer : IVF·Y UmaokaT Mori
Oct 13, 1995·The Journal of Biological Chemistry·Y ZhaoJ M Baltz
Oct 18, 2000·Proceedings of the National Academy of Sciences of the United States of America·J W Brewer, J A Diehl
Jan 27, 2005·Journal of Cellular Physiology·Candace L Steeves, Jay M Baltz
Mar 8, 2007·Molecular Reproduction and Development·Christoph G BaumannHenry J Leese
Nov 6, 2007·Antioxidants & Redox Signaling·Jyoti D Malhotra, Randal J Kaufman
Jun 26, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Erica LoudenKelle H Moley
Jun 9, 2009·Development·Alina P TartiaJay M Baltz
Jul 4, 2009·Molecular Endocrinology·Qiang WangKelle H Moley
Feb 20, 2010·The Journal of Reproduction and Development·Kiho LeeZoltan Machaty
Mar 17, 2010·Mitochondrion·Qiang Wang, Kelle H Moley
Mar 31, 2010·Stem Cell Reviews and Reports·Miguel Angel Blanco-GelazCarlos Lopez-Larrea
Aug 5, 2010·Journal of Cell Science·Elke MalzerStefan J Marciniak
Jun 1, 2011·Journal of Assisted Reproduction and Genetics·Scott H Purcell, Kelle H Moley
Jul 14, 2011·Biochemical and Biophysical Research Communications·Yongye HuangHongsheng Ouyang
Dec 14, 2011·Reproduction in Domestic Animals = Zuchthygiene·J-S KimD-B Koo
Jan 14, 2012·Reproduction in Domestic Animals = Zuchthygiene·J HuH Wang
Mar 8, 2012·Reproduction, Fertility, and Development·Tom P FlemingJudith J Eckert
Mar 13, 2012·Reproduction : the Official Journal of the Society for the Study of Fertility·Henry J Leese
Mar 28, 2012·The Journal of Reproduction and Development·Masashi Takahashi
Jan 24, 2013·The Journal of Biological Chemistry·Sally E ThomasStefan J Marciniak
Apr 25, 2013·Molecular Human Reproduction·Natalia M Grindler, Kelle H Moley

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Citations

Feb 14, 2016·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Nesrine Boudour-BouchekerCatherine Lorin-Nebel
Nov 29, 2017·Experimental & Applied Acarology·Nicole O Moura-MartinianoCarlos Augusto Gomes Soares
Apr 22, 2015·Journal of Assisted Reproduction and Genetics·Nina Van BeirsCandice Autin
Jan 18, 2020·Nature Communications·Kerrie L MariePravin J Mishra
Jun 10, 2020·Molecular Human Reproduction·Isao TakeharaSatoru Nagase
Jan 23, 2021·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Yuan-Jing ZouShao-Chen Sun
Mar 9, 2021·Frontiers in Cell and Developmental Biology·Elisa Mariano PioltineMarcelo Fábio Gouveia Nogueira

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