Stress testing of electrically active FlexMEAs with simultaneous electrical recording in fluidic environment: Introduction of a new measurement setup

The Review of Scientific Instruments
Markus WesterhausenBoris Hofmann

Abstract

We present a measurement setup consisting of two fluid-filled pressure chambers to mimic the mechanical stress likely to that of small body movements on biomedical flexible micro-electrode arrays for the analysis of various degradation mechanisms. Our main goal was the simulation of micro-motions in fluid conditions, while maintaining an electric access to the device. These micro-motions would be likely to those occurring in the human body caused by the intracranial pressure in magnitudes of 7-25 mmHg, which translates to a fluid pressure of 9-33 mbar. Furthermore, severe mechanical stress can be administered to the samples under the previously mentioned environment. Therefore, a flexible, polyimide-based sample with various metal test structures was fabricated and analyzed in the presented measurement setup. A comparison of the elongation of the sample's surface as a function of the applied hydrostatic pressure is given with computer simulations.

References

Jan 5, 2002·Biomaterials·Hugo HämmerleMartin Stelzle
Feb 9, 2002·Science·Eberhart Zrenner
Nov 18, 2003·Artificial Organs·James D Weiland, Mark S Humayun
Jun 3, 2008·Neurologic Clinics·Leonardo Rangel-CastillaClaudia S Robertson
Mar 16, 2013·Biomedical Microdevices·Rene Patrick von Metzen, Thomas Stieglitz
Aug 1, 2014·Biomedical Microdevices·Wigand PoppendieckKlaus-Peter Hoffmann
Jan 13, 2017·European Journal of Translational Myology·Adrien DebelleAnne Vanhoestenberghe

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