Stress triggered rise in plasma aldosterone is lessened by chronic nicotine infusion

European Journal of Pharmacology
Charles T StierE L Sabban

Abstract

The ability of nicotine infusion to modulate plasma aldosterone levels in response to different stressors was investigated. Sprague-Dawley rats given nicotine (5 mg/kg/day) or saline for 14 days were subjected to stress. Baseline plasma aldosterone (86+/-17 pmol/l) was unaffected by nicotine. Aldosterone was significantly elevated by restraint (450+/-72 pmol/l) and especially with cold (1249+/-172 pmol/l) or immobilization (1779+/-247 pmol/l) stress. Nicotine infusion attenuated the rise in aldosterone with restraint and cold stress, but not immobilization. These results reveal that nicotine infusion can attenuate the aldosterone response, depending on the type of stress.

References

Dec 4, 1989·Neuroscience Letters·L L MinerB B Kaplan
Jan 1, 1988·Annual Review of Physiology·S J Quinn, G H Williams
Dec 29, 1995·Annals of the New York Academy of Sciences·G AguileraB S Akbasak
May 1, 1997·General Pharmacology·R H FosterM O Bustamante
Jan 15, 1998·The New England Journal of Medicine·B S McEwen
Aug 8, 1998·Clinical Pharmacology and Therapeutics·S ZevinN L Benowitz
Oct 5, 2001·Trends in Endocrinology and Metabolism : TEM·J W Funder
Jan 5, 2002·The New England Journal of Medicine·K T Weber

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Citations

Jul 18, 2012·Bulletin of Experimental Biology and Medicine·T A ObutT A Erdinieva
Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenBurt M Sharp
Sep 23, 2009·Journal of Cardiovascular Pharmacology·Erwan HeylenGabor Kaley
Oct 19, 2006·Chiropractic & Osteopathy·Katie Hardy, Henry Pollard
Jun 16, 2007·Biological Psychiatry·Andras Bilkei-GorzoAndreas Zimmer
Dec 6, 2005·Pharmacology, Biochemistry, and Behavior·Shu-Yuan ChengEsther L Sabban
Jul 6, 2019·Current Protein & Peptide Science·Daniela JezovaNatasa Hlavacova

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