PMID: 7041837May 1, 1982

Stress ulcers during live Escherichia coli sepsis. The role of acid and bile

Annals of Surgery
M Rees, J C Bowen

Abstract

This study was designed to define the conditions that will consistently produce stress ulcers following the systemic infusion of live E. coli (1.0-1.6 X 10(10) organisms/kg/hr). Using gold-filled oxygen microelectrodes and the in vivo gastric chamber model in dogs, the authors found that the intracellular oxygen tension of the superficial gastric epithelium declined during sepsis despite maintenance of total gastric blood flow. This hypoxia persisted for the three-hour experiment when normal saline bathed the gastric surface (n = 6). Adding 1-mM taurocholate (Tc) (n = 6) or 80-mM hydrochloric acid (HCl) (n = 6) to the gastric chamber improved the cellular hypoxia induced by sepsis, and no ulcers were produced. However, addition of physiologic concentrations of bile in acid (1-mM Tc in 80-mM HCl) produced widespread ulceration of the mucosa within 30 minutes in nine of ten dogs. These experiments demonstrate that epithelial hypoxia induced by sepsis predisposes the gastric mucosa to ulcerate in the presence of physiologic concentrations of topical acid and bile.

References

Jul 1, 1978·The Journal of Surgical Research·J C BowenE D Jacobson
May 1, 1972·Annals of Surgery·W A AltemeierJ J McDonough
Feb 1, 1972·Surgery·K N Hamza, L DenBesten
Mar 1, 1981·World Journal of Surgery·W P Ritchie
Nov 1, 1980·The Journal of Clinical Investigation·W C Duane, D M Wiegand
Jul 1, 1967·Proceedings of the Society for Experimental Biology and Medicine·H W Davenport

Citations

Nov 1, 1983·Annals of Surgery·L O NilssonL Wise
Aug 1, 1987·Scandinavian Journal of Gastroenterology·S ArvidssonU Haglund
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·U Haglund

Related Concepts

Anoxemia
Biliary Sludge
Canis familiaris
Escherichia Coli Infections
Gastric Acid
Structure of Pyloric Gland
Stomach
Gastric Ulcer

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