Stress urinary incontinence following vaginal trauma involves remodeling of urethral connective tissue in female mice

European Journal of Obstetrics, Gynecology, and Reproductive Biology
Huey-Yi ChenWen-Chi Chen

Abstract

The molecular mechanisms underlying stress urinary incontinence (SUI) are not clear. This study was conducted to evaluate molecular alterations in the urethras of mice with experimentally induced SUI. Eighteen virgin female mice were equally distributed into three groups as follows: two groups undergoing vaginal distension (VD) for 1 h with 3 mm and 8 mm dilators each, and a non-instrumented control group. Changes in leak point pressure (LPP), morphology, lysyl oxidase (LOX) expression and the metabolism of urethral connective tissue were assessed. The LPP was significantly decreased in the 3 mm and 8 mm VD groups compared with that in the control group. Collagen and elastin expression in the urethra was significantly decreased in the 8 mm VD group compared with that in the control group, while LOX expression was significantly enhanced. SUI following vaginal trauma involves over-expression of LOX and decreased synthesis of extracellular matrix components or increased proteolysis in the urethra.

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Citations

Sep 24, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Huey-Yi ChenChuan-Mu Chen
Sep 24, 2015·Prostate Cancer and Prostatic Diseases·Q HeS Gupta
Apr 9, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Yung-Hsiang ChenHuey-Yi Chen
Jul 10, 2014·The American Journal of Chinese Medicine·Yung-Hsiang ChenHuey-Yi Chen
Oct 3, 2014·PloS One·Yung-Hsiang ChenHuey-Yi Chen
Mar 30, 2017·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·Huey-Yi ChenYung-Hsiang Chen
Apr 13, 2020·Chinese Journal of Integrative Medicine·Yung-Hsiang ChenHuey-Yi Chen
Oct 12, 2018·Expert Opinion on Pharmacotherapy·Riccardo Bientinesi, Emilio Sacco

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